Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

395 questions · 407 findings · 33 reviews · Headline outcomes only

No studies found 113 · 27.8%GRADE not reported 39 · 9.6%Very low 91 · 22.4%Low 105 · 25.8%Moderate 50 · 12.3%High 9 · 2.2%

Summary of findings: insulin degludec vs insulin glargine

Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring from 22:00 to 06:59 h

Summary of findings: insulin degludec showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin glargine (low certainty).

1 finding from 1 review

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

Fetal anomaly (major) · pregnant women with pre‐existing diabetes

It is very uncertain whether insulin Detemir + prandial insulin Aspart changes fetal anomaly (major) compared with NPH insulin + prandial insulin Aspart (Different insulin types… (very low certainty).

1 finding from 1 review