Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

885 questions · 903 findings · 72 reviews

No studies found 106 · 11.7%GRADE not reported 45 · 5%Very low 114 · 12.6%Low 238 · 26.4%Moderate 314 · 34.8%High 86 · 9.5%

Summary of findings ‐ Inhaled mannitol vs dornase alfa

Lung function: FEV1 mL (percentage change from baseline) · children and young adults with CF

It is very uncertain whether summary of findings ‐ Inhaled mannitol changes lung function: FEV1 mL (percentage change from baseline) compared with dornase alfa (very low certainty).

1 finding from 1 review

Summary of findings ‐ Inhaled mannitol vs dornase alfa

Lung function: FEF25‐75 mL/s (percentage change from baseline) · children and young adults with CF

It is very uncertain whether summary of findings ‐ Inhaled mannitol changes lung function: FEF25-75 mL/s (percentage change from baseline) compared with dornase alfa (very low certainty).

1 finding from 1 review