Findings

What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

Silboesterol vs placebo

Immediate side effects of treatment · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Silboesterol vs placebo

Effect on later sexual function · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Silboesterol vs placebo

Other untoward side effects of treatment · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Silboesterol vs placebo

Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sildenafil vs placebo

Detumescence · men and boys with SCD and stuttering priapism

The review found no eligible studies for this question.

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sildenafil vs placebo

Reduction in frequency of priapism · men and boys with SCD and stuttering priapism

Sildenafil showed no clear difference in reduction in frequency of priapism compared with placebo (low certainty).

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 0.58 [0.07, 4.95]
1 study · 13 participants
Low

Sildenafil vs placebo

Immediate side effects of treatment · men and boys with SCD and stuttering priapism

1 finding from 1 review

Treatments for priapism in boys and men with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Low

Summary of findings ‐ Niprisan® vs placebo

Frequency, severity or duration of painful crises · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
70 participants
Low

Summary of findings ‐ Ciklavit® vs placebo

Frequency of hospital admissions from severe complications of SCD · people with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Ciklavit® vs placebo

Any adverse events including hepatic and renal toxicity · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Low

Summary of findings ‐ Ciklavit® vs placebo

Frequency of blood transfusion · people with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Ciklavit® vs placebo

Level of anaemia: packed cell volume · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
Low

Summary of findings ‐ Ciklavit® vs placebo

Quality of life measures · people with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Pfaffia paniculata vs placebo

Frequency, severity or duration of painful crises · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Pfaffia paniculata vs placebo

Frequency of severe complications of SCD · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Pfaffia paniculata vs placebo

Frequency of hospital admissions from severe complications of SCD · children with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Pfaffia paniculata vs placebo

Any adverse events including hepatic and renal toxicity · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Pfaffia paniculata vs placebo

Frequency of blood transfusion · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Summary of findings ‐ Niprisan® vs placebo

Frequency of severe complications of SCD · people with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
70 participants
Low

Summary of findings ‐ Pfaffia paniculata vs placebo

Level of anaemia: packed cell volume · children with SCD

1 finding from 1 review

Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low