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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

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No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Topical brimonidine vs vehicle

Physician‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole vs placebo

Proportion of participants with adverse event · Participants with rosacea

Metronidazole showed no clear difference in proportion of participants with adverse event compared with placebo (high certainty).

1 finding from 1 review

Topical brimonidine vs vehicle

Lesion count ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Topical brimonidine vs vehicle

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Metronidazole probably leads to higher physician‐assessed improvement in rosacea severity compared with placebo (moderate certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

QoL · Participants with rosacea

Topical ivermectin leads to higher HRQOL DLQI, proportion of participants that reported at end of study… compared with topical metronidazole (high certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Topical ivermectin leads to higher participant‐assessed improvement in rosacea severity Likert scale ‐… compared with topical metronidazole (high certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Proportion of participants with adverse event · Participants with rosacea

Topical ivermectin showed no clear difference in proportion of participants with adverse event compared with topical metronidazole (moderate certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Topical ivermectin leads to higher physician‐assessed improvement in rosacea severity compared with topical metronidazole (high certainty).

1 finding from 1 review