Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

Droperidol vs haloperidol

Mental state: mean score by 13 days (Scale for Quantification of Psychotic Symptom Severity, high = poor) · acute psychosis

Droperidol showed no clear difference in mental state: mean score by 13 days (Scale for Quantification of… compared with haloperidol (low certainty).

1 finding from 1 review

Droperidol vs midazolam

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol showed no clear difference in global state: use of additional medication ‐ by 60 minutes after… compared with midazolam (moderate certainty).

1 finding from 1 review

Droperidol vs placebo

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with placebo (high certainty).

1 finding from 1 review

Droperidol vs OLANZAPINE

Tranquillisation or asleep: tranquillised/asleep ‐ by around 30 minutes · acute psychosis

Droperidol showed no clear difference in tranquillisation or asleep: tranquillised/asleep ‐ by around 30… compared with olanzapine (high certainty).

1 finding from 1 review

Droperidol vs OLANZAPINE

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with olanzapine (high certainty).

1 finding from 1 review

Droperidol vs placebo

Adverse effects ‐ cardiovascular ‐ arrhythmia · acute psychosis

Droperidol showed no clear difference in adverse effects ‐ cardiovascular ‐ arrhythmia compared with placebo (moderate certainty).

1 finding from 1 review

Droperidol vs placebo

Adverse effects ‐ respiratory ‐ airway obstruction · acute psychosis

Droperidol showed no clear difference in adverse effects ‐ respiratory ‐ airway obstruction compared with placebo (low certainty).

1 finding from 1 review