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What do systematic reviews say?

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Evidence found and GRADE certainty

1,368 questions · 1,413 findings · 89 reviews · Common Mental Disorders

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No studies found 232 · 16.4%GRADE not reported 82 · 5.8%Very low 395 · 28%Low 331 · 23.4%Moderate 341 · 24.1%High 32 · 2.3%

Any early psychological intervention vs inactive control (usual care care, attention control, waitlist)

PTSD diagnosis · various

Any early psychological intervention may leads to lower PTSD diagnosis: 3–6 months compared with waiting list/usual care (low certainty).

2 findings from 1 review

Agomelatine vs placebo

Adverse events as N of participants with at least one adverse event subjective and objective · adults with a history of SAD

It is very uncertain whether agomelatine changes number of persons with at least one adverse event within a year compared with placebo (very low certainty).

1 finding from 1 review

Agomelatine vs placebo

Number of participants experiencing at least one severe adverse event · adults with a history of SAD

It is very uncertain whether agomelatine changes number of persons with at least one severe adverse event within a year compared with placebo (very low certainty).

1 finding from 1 review