Findings

What do systematic reviews say?

1,281 questions · 1,307 findings · 212 reviews

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No studies found 256 · 19.6%GRADE not reported 125 · 9.6%Very low 266 · 20.4%Low 403 · 30.8%Moderate 208 · 15.9%High 49 · 3.7%

CLOZAPINE vs Typical antipsychotics

Adverse effects: 1. Blood problems ‐ decreased white cell count · patients with schizophrenia

CLOZAPINE probably leads to higher adverse effects: 1. Blood problems ‐ decreased white cell count compared with TYPICAL ANTIPSYCHOTICS ‐ OVERALL (moderate certainty).

1 finding from 1 review

Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
RR 7.09 [1.96, 25.62]
13 studies · 1031 participants
Moderate