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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

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No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Chemical peeling vs needling

Investigator‐assessed adverse events (short‐term) · people with acne scars

Chemical peeling showed no clear difference in investigator‐assessed adverse events (short‐term) N of participants… compared with needling (low certainty).

1 finding from 1 review

Chemical peeling vs needling

Participant‐assessed adverse events (short‐term) N of participants with positive adverse events · people with acne scars

It is very uncertain whether chemical peeling changes participant‐assessed adverse events (short‐term) N of participants… compared with needling (very low certainty).

1 finding from 1 review

Chemical peeling vs needling

Patient satisfaction Number of satisfied patients · people with acne scars

It is very uncertain whether chemical peeling changes patient satisfaction N of satisfied participants compared with needling (very low certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Participant‐reported scar improvement (short‐term) N of participants with > 50% improvement in acne scars · people with acne scars

Injectable fillers probably leads to higher participant‐reported scar improvement (short‐term) N of participants… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Fractional laser vs non‐fractional non‐ablative laser

Participant‐assessed adverse events (short‐term) Burning N of participants with adverse events · people with acne scars

It is very uncertain whether fractional laser changes participant‐assessed adverse events (short‐term) Burning N of… compared with non‐fractional non‐ablative laser (very low certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Patient satisfaction Number of satisfied patients · people with acne scars

Injectable fillers probably leads to higher participant satisfaction N of satisfied participants compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Participant‐assessed adverse events (short‐term) N of participants with positive adverse events · people with acne scars

Injectable fillers showed no clear difference in participant‐reported adverse events (short‐term) N of participants… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Injectable fillers vs placebo or no treatment

Investigator‐assessed adverse events (short‐term) N of participants with positive adverse events · people with acne scars

Injectable fillers showed no clear difference in investigator‐assessed adverse events (short‐term) N of participants… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Fractional laser vs radiofrequency

Participant‐reported scar improvement (long‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Fractional laser vs radiofrequency

Participant‐reported scar improvement (short‐term) N of participants with > 50% improvement in acne scars · people with acne scars

It is very uncertain whether fractional laser changes participant‐reported scar improvement (short‐term) N of participants… compared with radiofrequency (very low certainty).

1 finding from 1 review

Fractional laser vs radiofrequency

Investigator‐assessed adverse events (short‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Azelaic acid vs placebo

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Azelaic acid leads to higher participant‐assessed improvement in rosacea severity Marked… compared with placebo (high certainty).

1 finding from 1 review

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in physician‐assessed improvement in rosacea severity Investigator's… compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review