HRQoL ‐ all domains (change from baseline) Scale: age‐appropriate versions of the CFQ‐R questionnaire · children and young adults with CF
1 finding from 1 review
Lung function: FEV1 mL (percentage change from baseline) · children and young adults with CF
It is very uncertain whether summary of findings ‐ Inhaled mannitol changes lung function: FEV1 mL (percentage change from baseline) compared with dornase alfa (very low certainty).
1 finding from 1 review
FEV1 % predicted · children and young adults with CF
The review found no eligible studies for this question.
1 finding from 1 review
FVC · children and young adults with CF
It is very uncertain whether summary of findings ‐ Inhaled mannitol changes lung function: FVC mL (percentage change from baseline) compared with dornase alfa (very low certainty).
1 finding from 1 review
Lung function: FEF25‐75 mL/s (percentage change from baseline) · children and young adults with CF
It is very uncertain whether summary of findings ‐ Inhaled mannitol changes lung function: FEF25-75 mL/s (percentage change from baseline) compared with dornase alfa (very low certainty).
1 finding from 1 review
Adverse events relating to treatment Scale: mild, moderate, severe and total · children and young adults with CF
1 finding from 1 review
HRQoL ‐ all domains (change from baseline) Scale: age‐appropriate versions of the CFQ‐R questionnaire · adults, children and young people with CF
1 finding from 1 review
Lung function: FEV1 mL (change from baseline) · adults, children and young people with CF
1 finding from 1 review
FEV1 % predicted: absolute change from baseline · adults, children and young people with CF
1 finding from 1 review
Major bleeding · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy
1 finding from 1 review
Thrombosis‐related mortality ‐ not reported · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life ‐ not reported · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Asymptomatic venous thromboembolism ‐ not reported · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events: clinically relevant non‐major bleeding / heparin‐induced thrombocytopenia ‐ not reported · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality ‐ not reported · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
First‐time symptomatic venous thromboembolism · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy
1 finding from 1 review
Seizure cessation: within 5 minutes to 1 hour · Children with acute tonic‐clonic seizures
It is very uncertain whether summary of findings ‐ Buccal midazolam changes seizure cessation: within 5 minutes to 1 hour compared with rectal diazepam (very low certainty).
1 finding from 1 review
Time from drug administration to of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
Summary of findings ‐ Buccal midazolam showed no clear difference in incidence of respiratory depression compared with rectal diazepam (low certainty).
1 finding from 1 review
Additional drugs required to stop the seizure: intravenous lorazepam required · Children with acute tonic‐clonic seizures
Summary of findings ‐ Buccal midazolam may leads to lower additional drugs required to stop the seizure: intravenous lorazepam… compared with rectal diazepam (low certainty).
1 finding from 1 review