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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

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No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Fractional laser vs combined chemical peeling plus needling

Participant‐assessed adverse events (short‐term) N of participants with adverse events · people with acne scars

It is very uncertain whether fractional laser changes participant‐assessed adverse events (short‐term) N of participants… compared with combined chemical peeling plus needling (very low certainty).

1 finding from 1 review

Fractional laser vs non‐fractional non‐ablative laser

Participant‐reported scar improvement (short‐term) N of participants with > 50% improvement in acne scars · people with acne scars

It is very uncertain whether fractional laser changes participant‐reported scar improvement (short‐term) N of participants… compared with non‐fractional non‐ablative laser (very low certainty).

1 finding from 1 review

Chemical peeling vs placebo or no treatment

Serious or severe adverse events N of participants with positive severe adverse events · people with acne scars

It is very uncertain whether chemical peeling changes serious or severe adverse events N of participants with positive… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Chemical peeling vs combined chemical peeling plus any active intervention

Participant‐reported scar improvement (long‐term) · people with acne scars

It is very uncertain whether chemical peeling changes participant‐reported scar improvement (long‐term) N of participants… compared with combined chemical peeling plus any active intervention (very low certainty).

1 finding from 1 review

Chemical peeling vs combined chemical peeling plus any active intervention

Participant‐assessed adverse events (short‐term) N of participants with adverse events · people with acne scars

It is very uncertain whether chemical peeling changes participant‐assessed adverse events (short‐term) N of participants… compared with combined chemical peeling plus any active intervention (very low certainty).

1 finding from 1 review

Fractional laser vs non‐fractional non‐ablative laser

Adverse events ‐ hyperpigmentation ( · people with acne scars

It is very uncertain whether fractional laser changes investigator‐assessed adverse events (short‐term) Hyperpigmentation… compared with non‐fractional non‐ablative laser (very low certainty).

1 finding from 1 review

Chemical peeling vs needling

Participant‐reported scar improvement (long‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Chemical peeling vs needling

Participant‐reported scar improvement (short‐term) N of participants with > 50% improvement in acne scars · people with acne scars

It is very uncertain whether chemical peeling changes participant‐reported scar improvement (short‐term) N of participants… compared with needling (very low certainty).

1 finding from 1 review