Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

WENDAN DECOCTION vs placebo or no treatment

Global state: Clinically important change ‐ no improvement ‐ defined as PANSS < 50% reduction (short term) · patients with schizophrenia

WENDAN DECOCTION may leads to lower global state: Clinically important change ‐ no improvement ‐ defined… compared with PLACEBO OR NO TREATMENT (low certainty).

1 finding from 1 review

WENDAN DECOCTION vs antipsychotics

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

WENDAN DECOCTION probably leads to lower adverse effects: Movement disorders ‐ Extra Pyramidal Symptoms… compared with ANTIPSYCHOTIC DRUG (moderate certainty).

1 finding from 1 review

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC vs STANDARD DOSE ANTIPSYCHOTICS

Global state: Clinically important change ‐ no improvement ‐ defined as PANSS < 50% reduction (short term) · patients with schizophrenia

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC probably leads to lower global state: Clinically important change ‐ no improvement ‐ defined… compared with NORMAL DOSE ANTIPSYCHOTIC (moderate certainty).

1 finding from 1 review

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC vs STANDARD DOSE ANTIPSYCHOTICS

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC probably leads to lower adverse effects: Movement disorders ‐ Extra Pyramidal Symptoms… compared with NORMAL DOSE ANTIPSYCHOTIC (moderate certainty).

1 finding from 1 review

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC vs STANDARD DOSE ANTIPSYCHOTICS

Adverse effects: Metabolic ‐ weight change (medium term) · patients with schizophrenia

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC showed no clear difference in adverse effects: Metabolic ‐ weight change (medium term) compared with NORMAL DOSE ANTIPSYCHOTIC (low certainty).

1 finding from 1 review