Findings

What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm)

Need for extra treatment · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm)

FEV1 % predicted: absolute change from baseline · adults with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 4 participants
Very low

Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm)

QoL · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm)

Participant preference · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs conventional physiotherapy

Hospital admissions · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm)

Exercise tolerance (modified shuttle test) · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm)

Adverse events · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm)

Hospital admissions · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm)

Need for extra treatment · adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs conventional physiotherapy

Need for extra treatment · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Autogenic drainage vs spontaneous cough

FEV1 % predicted · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Autogenic drainage vs spontaneous cough

QoL · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

12MWT: change from baseline in m walked · children and adults with mucopolysaccharidosis type VI

1 finding from 1 review

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Very low

Intervention not reported

3MSC: change in 3MSC rates (stairs/min) from baseline · children and adults with mucopolysaccharidosis type VI

1 finding from 1 review

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Very low

Intervention not reported

6MWT: change from baseline in m walked · children and adults with mucopolysaccharidosis type VI

1 finding from 1 review

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Very low

Intervention not reported

Respiratory tests: absolute change from baseline in FVC (L) · children and adults with mucopolysaccharidosis type VI

1 finding from 1 review

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Very low

Intervention not reported

Cardiac function Â · children and adults with mucopolysaccharidosis type VI

The review found no eligible studies for this question.

1 finding from 1 review

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

GAG level: change in urinary GAG level from baseline ųg/mg creatinine · children and adults with mucopolysaccharidosis type VI

1 finding from 1 review

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Intervention not reported

AEs: drug‐related AEs · children and adults with mucopolysaccharidosis type VI

It is very uncertain whether the intervention changes AEs: drug‐related AEs (very low certainty).

1 finding from 1 review

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI 2021 · Cochrane Headline outcomes only
RR 1.93 [0.89, 4.17]
1 study · 39 participants
Very low

Cisapride vs placebo

Radiological diagnosis of DIOS (physician‐measured radiological scores) · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low