What do systematic reviews say?

Aciclovir (oral or intravenous) for treatment vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  For the treatment comparison (aciclovir versus placebo), no data were available for recurrence of lesions, amount of analgesia, days of stay in hospital, cost of oral care or patient quality of life.
  0 studies
  No studies found

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

Enamel matrix derivative (EMD; Emdogain) showed no clear difference in aesthetics compared with placebo or control (same surgical or non-surgical intervention… (low certainty).

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  MD 1.0 [-5.4, 7.4]
  1 study · 166 participants
  Low

Aciclovir (oral or intravenous) for treatment vs placebo

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  Two studies. Statistically significant difference in median duration of virus shedding in favour of intravenous aciclovir (2.5 days versus 17.0 days, P = 0.0002; Meyers 1982) and oral aciclovir (2 days versus more than…
  2 studies
  GRADE not reported

Prophylactic aciclovir (oral or intravenous) vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  None of the prophylactic aciclovir versus placebo trials reported on patient quality of life. For prevention or treatment, no trials reported on duration of hospital stay, amount of analgesia or patient quality of life.
  0 studies
  No studies found

Aciclovir (oral or intravenous) for treatment vs placebo

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  Time to first decrease in pain was significantly shorter in favour of oral aciclovir (median 3 days versus 16 days, P = 0.04; Shepp 1985). Time to complete resolution of pain was shorter with oral aciclovir than…
  2 studies
  GRADE not reported

Any denture cleansing method (mechanical or chemical) vs Another method, sham/placebo, or no treatment

• Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
  Although six RCTs were included in this review, the wide range of different interventions and outcome variables did not permit pooling of data in a meta-analysis. Isolated reports indicated that chemicals and brushing…
  6 studies
  GRADE not reported

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  Adverse events were not described separately for each group. Trialists reported that adverse events were in most patients minimal and consisted of nausea, flushes and some dizziness. One patient had diarrhoea which…
  1 study · 14 participants
  GRADE not reported

Aciclovir (oral or intravenous) for treatment vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  For the treatment comparison (aciclovir versus placebo), no data were available for recurrence of lesions, amount of analgesia, days of stay in hospital, cost of oral care or patient quality of life.
  0 studies
  No studies found

Prophylactic aciclovir (oral or intravenous) vs placebo

Prophylactic aciclovir (oral or intravenous) led to lower viral isolates (HSV isolates identified, with or without clinical… compared with placebo; GRADE not reported.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  RR 0.17 [0.07, 0.37]
  9 studies · 511 participants
  GRADE not reported

Aciclovir (oral or intravenous) for treatment vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  For the treatment comparison (aciclovir versus placebo), no data were available for recurrence of lesions, amount of analgesia, days of stay in hospital, cost of oral care or patient quality of life.
  0 studies
  No studies found

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

Enamel matrix derivative (EMD; Emdogain) showed no clear difference in change in gingival recession (REC) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  MD 0.02 [-0.3, 0.3]
  6 studies · 302 participants
  Low

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  No statistically significant difference between EMD and control for radiographic bone gain (three trials; P effect = 0.27, I2 = 78%).
  3 studies
  GRADE not reported

Enzyme cleanser vs Placebo / sham solution

• Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes

  12 weeks
  Lower hyphal and bacterial scores were also found for 'E' when compared with 'Plac' after 12 weeks. It was not possible to extract adequate data as the investigators did not provide standard deviations.
  1 study
  GRADE not reported

Any denture cleansing method (mechanical or chemical) vs Another therapy, placebo, or no treatment

The review found no eligible studies for this question.

• Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
  Noticeable absence of reports about adverse effects; no included study assessed the extent of adverse effects (for example the aftertaste of sodium hypochlorite, or mechanical or chemical damage to denture materials)…
  0 studies
  No studies found

Silicone surfactant cleanser vs Placebo / sham solution

Silicone surfactant cleanser led to lower visual plaque score compared with placebo / sham solution; GRADE not reported.

• Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes

  14 days
  MD -0.88 [-1.00, -0.76]
  1 study
  GRADE not reported
• Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes

  2 days
  MD -1.02 [-1.13, -0.91]
  1 study
  GRADE not reported

Prophylactic aciclovir (oral or intravenous) vs placebo

Prophylactic aciclovir (oral or intravenous) led to lower presence/absence of HSV oral lesions compared with placebo; GRADE not reported.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  RR 0.16 [0.08, 0.31]
  9 studies · 398 participants
  GRADE not reported

Enzyme cleanser vs Placebo / sham solution

Enzyme cleanser led to lower improvement on denture cleanliness (caregivers' opinion) compared with placebo / sham solution; GRADE not reported.

• Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes

  12 weeks
  After 12 weeks using an enzyme denture cleanser ('E'), 8 of 18 caregivers perceived some improvement in CD cleanliness. After using a placebo solution ('Plac'), only 2 of 17 perceived some improvement (Analysis 1.1,…
  1 study · 35 participants
  GRADE not reported

Ultrasound during vertical distraction osteogenesis vs Placebo (no ultrasound) during vertical distraction

Ultrasound during vertical distraction osteogenesis showed no clear difference in distraction distance (bone gain, mm) compared with placebo (no ultrasound) during vertical distraction; GRADE not reported.

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  2 years post-loading
  Distraction distance 4.6 mm (ultrasound) vs 5.8 mm (placebo); difference 1.2 mm not statistically significant, in favour of placebo; data not shown (Schortinghuis 2008)
  1 study · 9 participants
  GRADE not reported

Prophylactic aciclovir (oral or intravenous) vs placebo

The review found no eligible studies for this question.

• Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
  For prevention or treatment, no trials reported on duration of hospital stay, amount of analgesia or patient quality of life.
  0 studies
  No studies found

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

Enamel matrix derivative (EMD; Emdogain) may leads to higher change in probing pocket depth (PPD) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).

• Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes

  1 year (time-points 1, 5 and 10 years planned)
  MD 0.88 [0.44, 1.31]
  9 studies · 371 participants
  Low