Bone mineral density · children
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density (Whole body / total), Healthy children: SMD 0.1 (95% CI -0.06 to 0.26), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
SMD 0.1 [-0.06, 0.26]
5 studies
GRADE not reported
Hip/femoral bone mineral density (BMD) · children
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in hip, Healthy children: SMD 0.06 (95% CI -0.18 to 0.29), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
SMD 0.06 [-0.18, 0.29]
4 studies
GRADE not reported
Bone pain · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Bone pain: RR 0.29 (95% CI 0.03 to 2.63), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Bone mineral density · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density, Community-dwelling adults: WMD -0.9 (95% CI -2.10 to 0.40), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD -0.9 [-2.10, 0.40]
3 studies
GRADE not reported
Dental caries · children
Meta-analysis of randomised trials of vitamin D supplementation for Dental caries: RR 0.53 (95% CI 0.43 to 0.65), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
All cause mortality (in CKD patients) · Participants in observational studies
The meta-analysis of observational studies reported a RR of 0.88 (95% CI 0.81 to 0.93) for higher versus lower circulating vitamin D concentration.
1 finding from 1 review
Insulin resistance · Adults with diabetes
Meta-analysis of randomised trials of vitamin D supplementation for Insulin resistance (Diabetes): SMD 0.16 (95% CI -0.11 to 0.42), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
SMD 0.16 [-0.11, 0.42]
5 studies
GRADE not reported
Type 2 diabetes (prevalent) · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Type 2 diabetes (prevalent): OR 0.45 (95% CI 0.25 to 0.82), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
All cause mortality · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for All cause mortality: HR 0.72 (95% CI 0.66 to 0.78), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Rectal cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Rectal cancer: OR 0.50 (95% CI 0.29 to 0.88), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Intervention not reported
Comparison intervention
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
placebo
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
IFNß‐1a (Avonex)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
IFNß‐1a (Rebif)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
IFNß‐1b (Betaseron)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Glatiramer acetate
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
IFNß‐1a Avonex
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found