Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,411 questions · 1,474 findings · 170 reviews

No studies found 336 · 22.8%GRADE not reported 97 · 6.6%Very low 419 · 28.4%Low 395 · 26.8%Moderate 188 · 12.8%High 39 · 2.6%

Amifostine vs no otoprotective intervention

Ototoxicity according to NCI CTC v2 criteria with intravenous platinum (combined asymptomatic and symptomatic disease) Objective and subjective audiometric evaluations were performed, no further information provided · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in ototoxicity according to NCICTCv2 criteria with intravenous platinum… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Amifostine vs no otoprotective intervention

Ototoxicity according to modified Brock criteria with intravenous platinum (combined asymptomatic and symptomatic disease) Audiograms were performed, but no further information provided · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in ototoxicity according to modified Brock criteria with intravenous… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Amifostine vs no otoprotective intervention

Tumour response with intra‐arterial platinum (good and partial remission) · children with cancer treated with platinum‐based therapy

Amifostine showed no clear difference in tumour response with intra‐arterial platinum (good and partial… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Shock wave lithotripsy vs ureteroscopy with holmium laser or pneumatic lithotripsy

Serious adverse events or complications of treatment

It is very uncertain whether shock wave lithotripsy changes serious adverse events or complications of treatment compared with ureteroscopy with holmium laser or pneumatic lithotripsy (very low certainty).

1 finding from 1 review

Percutaneous nephrolithotripsy vs tubeless percutaneous nephrolithotripsy

Serious adverse events or complications of treatments

It is very uncertain whether percutaneous nephrolithotripsy changes serious adverse events or complications of treatments compared with tubeless percutaneous nephrolithotripsy (very low certainty).

1 finding from 1 review