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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

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No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone

Withdrawals due to adverse events · children and young people with JIA

Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in withdrawals due to adverse events(12 months) compared with intra‐articular glucocorticoid alone (low certainty).

1 finding from 1 review

Summary of findings: oral antioxidant combination vs control

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Adverse events · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

MACE · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in MACE compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

Death · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in death compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

All major occlusive vascular events · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in all major occlusive vascular events compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

Intracerebral haemorrhage (ICH) · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in intracerebral haemorrhage (ICH) compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Starting long‐term oral antiplatelet therapy vs avoiding antithrombotic therapy

Functional outcomes · survivors of stroke due to intracerebral haemorrhage

Summary of findings table ‐ Starting long‐term oral antiplatelet… showed no clear difference in fnctional status (mRS 0‐2) compared with avoiding antithrombotic therapy (moderate certainty).

1 finding from 1 review