Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Summary of findings: Fibrin sealant vs usual care

Risk of a thrombotic/thromboembolic event (MI, CVA, DVT, PE) · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Fibrin sealant changes risk of a thrombotic/thromboembolic event (MI, CVA, DVT, PE) compared with usual care (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Risk of receiving any allogeneic blood product (data only available for intraoperative blood product use) · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Tranexamic acid changes risk of receiving any allogeneic blood product (data only available… compared with placebo (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Risk of reoperation or repeat procedure for bleeding within 7 days · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Tranexamic acid changes risk of reoperation or repeat procedure for bleeding within 7 days compared with placebo (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Risk of a thrombotic/thromboembolic event (MI, CVA, DVT, PE) · people aged 18 and over undergoing vascular surgery

Summary of findings: Tranexamic acid showed no clear difference in risk of a thrombotic/thromboembolic event (MI, CVA, DVT, PE) compared with placebo (low certainty).

1 finding from 1 review

Summary of findings: Fibrin sealant vs usual care

All‐cause mortality up to 30 days · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Fibrin sealant changes all‐cause mortality up to 30 days compared with usual care (very low certainty).

1 finding from 1 review

Summary of findings: Fibrin sealant vs usual care

Risk of reoperation or repeat procedure for bleeding within 7 days · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Fibrin sealant changes risk of reoperation or repeat procedure for bleeding within 7 days compared with usual care (very low certainty).

1 finding from 1 review

Electrical or magnetic stimulation vs no treatment, sham treatment or verbal/written instruction

Number of participants experiencing surface or skin‐related adverse events: e.g. skin reactions, bruising, hypersensitivity to gel · men with urinary incontinence following prostate surgery

The review found no eligible studies for this question.

1 finding from 1 review

Electrical or magnetic stimulation vs no treatment, sham treatment or verbal/written instruction

Number of participants experiencing muscle‐related adverse events: e.g. soreness, discomfort, cramps, pain · men with urinary incontinence following prostate surgery

The review found no eligible studies for this question.

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Perception of improvement or cure · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in subjective cure or improvement: patient‐reported as defined by the… compared with no treatment, sham treatment or verbal/written instruction (low certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Disease‐specific quality of life · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in condition‐specific quality of life: using validated questionnaires,… compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Objective cure or improvement: > 6 to 12 months · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in objective cure or improvement: > 6 to 12 months compared with no treatment, sham treatment or verbal/written instruction (high certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Adherence · men with urinary incontinence following prostate surgery

It is very uncertain whether combinations of conservative treatments changes participant adherence to the intervention: as reported by the… compared with no treatment, sham treatment or verbal/written instruction (very low certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

QoL · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in general quality of life: > 6 to 12 months compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

1 finding from 1 review