Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomesshort-term (up to 3 months) · gabapentin with adjunctive ALA
SoF2 subgroup. Gabapentin + adjunctive ALA vs placebo forms one of two subgroups of the anticonvulsant symptom-relief estimate (RR 4.00, 2.09 to 7.67); no between-subgroup difference vs gabapentin alone; 100…
1 study · 40 participants
Very low
Oral health-related quality of life · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)
The review found no eligible studies for this question.
1 finding from 1 review
SoF row 'Oral health-related quality of life': Illustrative risks -, relative effect -, participants/studies -, quality -; Comment: Outcome not reported. Not measured in any included study.
0 studies
No studies found
Change in taste · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
The review found no eligible studies for this question.
1 finding from 1 review
QoL · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomesshort-term (up to 3 months)
SoF1. Change in QoL short-term (mean Beck Depression Inventory, 0-63, lower better): this single study narratively reported that both intervention and placebo participants were less depressed at trial completion, but…
1 study · 37 participants
Very low
Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 2, Clinical resolution (not completely resolved) at 5 to 12 months: 'The 3 studies could not be combined in meta-analysis. 2 found benefit for systemic beta carotene, and 1 did not.' No GRADE rating. Effects text…
3 studies
GRADE not reported
Plaque · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)
Educational intervention with information and practical components… showed no clear difference in dental plaque compared with (Optimised) usual care (low certainty).
1 finding from 1 review
Adverse events: worsening of hypertension · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
It is very uncertain whether dietary supplements (alpha lipoic acid +/- adjunctive ingredients) changes adverse effects: increase in blood pressure compared with placebo (very low certainty).
1 finding from 1 review
Adverse effects · People with squamous cell carcinoma of the oral cavity or oropharynx
Non-specific immunotherapy (recombinant interleukin-2 or BCG cell… showed no clear difference in adverse effects compared with standard therapy alone; GRADE not reported.
9 findings from 1 review
RR 11.00 [0.67, 179.29]
1 study · 24 participants
GRADE not reported
RR 3.40 [0.15, 77.34]
1 study · 30 participants
GRADE not reported
RR 1.47 [0.75, 2.90]
1 study · 30 participants
GRADE not reported
Show 6 more findings
RR 0.57 [0.22, 1.50]
1 study · 30 participants
GRADE not reported
RR 0.67 [0.13, 3.30]
1 study · 24 participants
GRADE not reported
RR 0.38 [0.04, 3.26]
1 study · 30 participants
GRADE not reported
RR 1.24 [0.90, 1.70]
1 study · 30 participants
GRADE not reported
RR 1.71 [0.33, 8.83]
1 study · 30 participants
GRADE not reported
RR 5.00 [0.27, 94.34]
1 study · 24 participants
GRADE not reported
Adverse effects · People with squamous cell carcinoma of the oral cavity or oropharynx
Tyrosine kinase inhibitor (erlotinib, gefitinib or lapatinib) plus… led to higher adverse effects compared with standard therapy alone (radiotherapy or chemoradiotherapy); GRADE not reported.
9 findings from 1 review
RR 2.02 [1.23, 3.32]
1 study · 67 participants
GRADE not reported
RR 1.04 [0.98, 1.11]
1 study · 226 participants
GRADE not reported
RR 15.53 [2.18, 110.55]
1 study · 67 participants
GRADE not reported
Show 6 more findings
RR 6.57 [3.60, 12.00]
1 study · 191 participants
GRADE not reported
RR 1.22 [0.96, 1.56]
2 studies · 286 participants
GRADE not reported
RR 1.03 [0.94, 1.11]
2 studies · 286 participants
GRADE not reported
RR 1.03 [0.82, 1.28]
2 studies · 286 participants
GRADE not reported
RR 1.11 [0.83, 1.49]
3 studies · 484 participants
GRADE not reported
RR 1.25 [0.54, 2.88]
4 studies · 544 participants
GRADE not reported
Occlusion (change in maxillary arch length, short term) · Children with a non-nutritive sucking habit (digit or pacifier)
1 finding from 1 review
Table 1 (reduction in malocclusion), Villa 1997 (n=24), palatal crib vs no treatment: change in maxillary arch length (mm) - no treatment 0.01 (SD 0.33); palatal crib -1.4 (SD 1.4); reported as statistically…
1 study · 24 participants
GRADE not reported
Adverse effects · People with squamous cell carcinoma of the oral cavity or oropharynx
10 findings from 1 review
Mucositis all grades: not estimable due to high heterogeneity (P=0.0009; I2=86%) between subgroups (cetuximab; nimotuzumab) and within cetuximab (I2=93%); 1417 participants, 3 studies. Table 3, row 1.6 (Ang 2014;…
3 studies · 1417 participants
GRADE not reported
RR 6.56 [5.35, 8.03]
2 studies · 1311 participants
GRADE not reported
RR 1.36 [0.80, 2.31]
2 studies · 1311 participants
GRADE not reported
Show 7 more findings
Adverse events · Children with a non-nutritive sucking habit (digit or pacifier)
1 finding from 1 review
Sucking cessation (long term) · Children with a non-nutritive sucking habit (digit or pacifier)
Orthodontic appliances (palatal crib) led to higher sucking cessation (long term) compared with no treatment; GRADE not reported.
1 finding from 1 review
Oral mucositis (severe) · All patients with cancer who are receiving treatment
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… probably leads to lower oral mucositis (severe) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (moderate certainty).
3 findings from 1 review
RR 0.38 [0.20, 0.72]
5 studies · 270 participants
Moderate
RR 0.88 [0.61, 1.25]
1 study · 122 participants
Very low
RR 0.40 [0.27, 0.61]
5 studies · 444 participants
Moderate
Repositioning of ankylosed teeth after osteotomy followed or not by distraction osteogenesis, or after luxation vs Conventional orthodontic treatment or follow-up with no specific treatment for ankylosis
Outcome not reported · Any patient with ankylosis and displacement of permanent front teeth diagnosed by clinical and radiographic assessment, with or without…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Oral mucositis (severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.2); 81 participants in…
1 study · 81 participants
GRADE not reported
Sucking cessation (short term) · Children with a non-nutritive sucking habit (digit or pacifier)
It is very uncertain whether palatal arch changes sucking cessation (short term) compared with palatal crib (alternative orthodontic appliance) (very low certainty).
1 finding from 1 review
Number of days of treatment with opioid analgesics · All patients with cancer who are receiving treatment
The review found no eligible studies for this question.
2 findings from 1 review
Disease-free survival · People with squamous cell carcinoma of the oral cavity or oropharynx
It is very uncertain whether non-specific immunotherapy (recombinant interleukin-2 or BCG cell… changes disease-free survival compared with standard therapy alone (very low certainty).
1 finding from 1 review