Findings

What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

Standard rhGH vs placebo

Number of pulmonary exacerbations or hospitalisations · children and young adults with CF

Standard rhGH showed no clear difference in number of pulmonary exacerbations or hospitalisations compared with placebo (low certainty).

1 finding from 1 review

Recombinant growth hormone therapy for cystic fibrosis in children and young adults 2021 · Cochrane Headline outcomes only
RR 1.5 [0.49, 4.59]
1 study · 44 participants
Low

Standard rhGH vs no treatment

FEV1 % predicted · children and young adults with CF

1 finding from 1 review

Recombinant growth hormone therapy for cystic fibrosis in children and young adults 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Standard rhGH vs no treatment

FVC · children and young adults with CF

1 finding from 1 review

Recombinant growth hormone therapy for cystic fibrosis in children and young adults 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Angiotensin‐converting enzyme inhibitors vs placebo

Urinary protein or albumin excretion ‐ total albumin excretion at 6 months · People with proteinuria or microalbuminuria due to sickle cell disease

1 finding from 1 review

Angiotensin‐converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Angiotensin‐converting enzyme inhibitors vs placebo

Creatinine level · People with proteinuria or microalbuminuria due to sickle cell disease

1 finding from 1 review

Angiotensin‐converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Angiotensin‐converting enzyme inhibitors vs placebo

Electrolyte levels · People with proteinuria or microalbuminuria due to sickle cell disease

1 finding from 1 review

Angiotensin‐converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Angiotensin‐converting enzyme inhibitors vs placebo

Blood pressure · People with proteinuria or microalbuminuria due to sickle cell disease

1 finding from 1 review

Angiotensin‐converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Angiotensin‐converting enzyme inhibitors vs placebo

Hemoglobin concentration (g/dL) · People with proteinuria or microalbuminuria due to sickle cell disease

1 finding from 1 review

Angiotensin‐converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Angiotensin‐converting enzyme inhibitors vs placebo

Adverse events or toxicity · People with proteinuria or microalbuminuria due to sickle cell disease

1 finding from 1 review

Angiotensin‐converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Autogenic drainage vs conventional physiotherapy

FEV1 % predicted: absolute change from baseline · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 54 participants
Very low

Autogenic drainage vs spontaneous cough

Participant preference · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs spontaneous cough

Exercise capacity · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs spontaneous cough

Adverse events · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Autogenic drainage vs spontaneous cough

Hospital admissions · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs spontaneous cough

Need for extra treatment · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Autogenic drainage vs active cycle of breathing technique

FEV1 (L) · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 44 participants
Low

Autogenic drainage vs active cycle of breathing technique

QoL · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Autogenic drainage vs active cycle of breathing technique

Participant preference · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 44 participants
Very low

Autogenic drainage vs active cycle of breathing technique

Exercise tolerance (modified shuttle test) · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Autogenic drainage vs active cycle of breathing technique

Adverse events · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low