Findings

What do systematic reviews say?

3,971 questions · 9,849 findings · 853 reviews

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No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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Doxycycline + SRP vs Metronidazole + SRP

Adverse events · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported adverse events
Studies not reported
No studies found

Doxycycline + SRP vs Metronidazole + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.05 [-0.22, 0.12]
1 study · 22 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Clindamycin + SRP vs Metronidazole + SRP

Patient-reported quality of life changes · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 0.17 [-1.28, 1.62]
1 study · 20 participants
GRADE not reported

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Probing pocket depth · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.14 [-0.12, 0.40]
2 studies · 50 participants
GRADE not reported

Doxycycline + SRP vs Metronidazole + SRP

Antimicrobial resistance · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

Clindamycin + SRP vs Metronidazole + SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Clindamycin + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 0.40 [-0.22, 1.02]
1 study · 26 participants
GRADE not reported

Clindamycin + SRP vs Metronidazole + SRP

Antimicrobial resistance · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included studies have not reported this outcome
Studies not reported
No studies found

LNG‐IUS vs endometrial ablation

Quality of life · heavy menstrual bleeding

1 finding from 1 review

Progestogen‐releasing intrauterine systems for heavy menstrual bleeding 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Very low

LNG‐IUS vs endometrial ablation

Adverse events · heavy menstrual bleeding

LNG‐IUS probably leads to higher adverse events compared with endometrial ablation (moderate certainty).

1 finding from 1 review

Progestogen‐releasing intrauterine systems for heavy menstrual bleeding 2020 · Cochrane Headline outcomes only
RR 2.06 [1.44, 2.94]
3 studies · 201 participants
Moderate

LNG‐IUS vs endometrial ablation

Treatment failure · heavy menstrual bleeding

LNG‐IUS may leads to higher treatment failure compared with endometrial ablation (low certainty).

1 finding from 1 review

Progestogen‐releasing intrauterine systems for heavy menstrual bleeding 2020 · Cochrane Headline outcomes only
RR 1.78 [1.09, 2.9]
5 studies · 320 participants
Low

LNG‐IUS vs endometrial ablation

Costs · heavy menstrual bleeding

1 finding from 1 review

Progestogen‐releasing intrauterine systems for heavy menstrual bleeding 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
GRADE not reported

LNG‐IUS vs endometrial ablation

Bleeding · heavy menstrual bleeding

1 finding from 1 review

Progestogen‐releasing intrauterine systems for heavy menstrual bleeding 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 122 participants
Very low

LNG‐IUS vs endometrial ablation

Satisfaction with treatment · heavy menstrual bleeding

LNG‐IUS showed no clear difference in satisfaction with treatment compared with endometrial ablation (low certainty).

1 finding from 1 review

Progestogen‐releasing intrauterine systems for heavy menstrual bleeding 2020 · Cochrane Headline outcomes only
RR 0.95 [0.85, 1.07]
5 studies · 317 participants
Low

Azathioprine vs methotrexate

Death · adults with renal vasculitis for maintenance therapy

Azathioprine may leads to lower death compared with methotrexate (low certainty).

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
RR 0.33
1 study · 126 participants
Low

Azathioprine vs methotrexate

Kidney function · adults with renal vasculitis for maintenance therapy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Azathioprine vs methotrexate

Dialysis · adults with renal vasculitis for maintenance therapy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Azathioprine vs methotrexate

Relapse · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in relapse compared with methotrexate (low certainty).

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
RR 1.1 [0.68, 1.77]
1 study · 126 participants
Low

Azathioprine vs methotrexate

Adverse event causing death or study drug discontinuation · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in adverse events causing death or study drug discontinuation compared with methotrexate (low certainty).

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
RR 0.58 [0.25, 1.38]
1 study · 126 participants
Low

Azathioprine vs methotrexate

Severe adverse events · adults with renal vasculitis for maintenance therapy

Azathioprine may leads to lower severe adverse events compared with methotrexate (low certainty).

1 finding from 1 review

Interventions for renal vasculitis in adults 2020 · Cochrane Headline outcomes only
RR 0.58
1 study · 126 participants
Low