What do systematic reviews say?

One week of AmBd + 5FC vs one week of AmBd + FLU

One week of AmBd + 5FC probably leads to lower mortality: 10 weeks compared with one week of AmBd + FLU (moderate certainty).

• Treatment for HIV‐associated cryptococcal meningitis 2018 · Cochrane Headline outcomes only
  RR 0.49 [0.34, 0.72]
  1 study · 224 participants
  Moderate

One week of AmBd + 5FC vs two weeks of 5FC + FLU

One week of AmBd + 5FC probably leads to lower mortality: 10 weeks compared with two weeks of 5FC + FLU (moderate certainty).

• Treatment for HIV‐associated cryptococcal meningitis 2018 · Cochrane Headline outcomes only
  RR 0.68 [0.47, 0.99]
  1 study · 338 participants
  Moderate

Two weeks of 5FC + FLU vs two weeks of AmBd + 5FC

Two weeks of 5FC + FLU showed no clear difference in mortality: 10 weeks compared with two weeks of AmBd + 5FC (moderate certainty).

• Treatment for HIV‐associated cryptococcal meningitis 2018 · Cochrane Headline outcomes only
  RR 0.92 [0.69, 1.23]
  1 study · 340 participants
  Moderate

Two weeks of 5FC + FLU vs two weeks of AmBd + FLU

Two weeks of 5FC + FLU showed no clear difference in mortality: 10 weeks compared with two weeks of AmBd + FLU (moderate certainty).

• Treatment for HIV‐associated cryptococcal meningitis 2018 · Cochrane Headline outcomes only
  RR 0.85 [0.64, 1.13]
  1 study · 339 participants
  Moderate

Two weeks of AmBd + 5FC vs two weeks of AmBd

Two weeks of AmBd + 5FC probably leads to lower mortality: 10 weeks compared with two weeks of AmBd (moderate certainty).

• Treatment for HIV‐associated cryptococcal meningitis 2018 · Cochrane Headline outcomes only
  RR 0.66 [0.46, 0.95]
  2 studies · 231 participants
  Moderate

Two weeks of AmBd + FLU vs two weeks of AmBd

Two weeks of AmBd + FLU showed no clear difference in mortality: 10 weeks compared with two weeks of AmBd (low certainty).

• Treatment for HIV‐associated cryptococcal meningitis 2018 · Cochrane Headline outcomes only
  RR 0.94 [0.55, 1.62]
  3 studies · 371 participants
  Low

Two weeks of AmBd + 5FC vs two weeks of AmBd + FLU

Two weeks of AmBd + 5FC showed no clear difference in mortality: 10 weeks compared with two weeks of AmBd + FLU (low certainty).

• Treatment for HIV‐associated cryptococcal meningitis 2018 · Cochrane Headline outcomes only
  RR 0.9 [0.69, 1.19]
  4 studies · 538 participants
  Low

Prosthetic mesh placement vs usual care

Prosthetic mesh placement may leads to lower overall incidence of parastomal hernia ( compared with standard treatment (low certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.53 [0.43, 0.66]
  10 studies · 771 participants
  Low

Prosthetic mesh placement vs usual care

Prosthetic mesh placement may leads to lower subgroup analysis:Incidence of parastomal hernia (laparoscopic… compared with standard treatment (low certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.64 [0.47, 0.87]
  3 studies · 153 participants
  Low

Prosthetic mesh placement vs usual care

Prosthetic mesh placement probably leads to lower subgroup analysis:Incidence of parastomal hernia (open surgery) ( compared with standard treatment (moderate certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.46 [0.34, 0.62]
  6 studies · 517 participants
  Moderate

Prosthetic mesh placement vs usual care

Prosthetic mesh placement probably leads to lower subgroup analysis:Incidence of parastomal hernia (sublay… compared with standard treatment (moderate certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.48 [0.36, 0.64]
  7 studies · 619 participants
  Moderate

Prosthetic mesh placement vs usual care

Prosthetic mesh placement showed no clear difference in subgroup analysis:Incidence of parastomal hernia (intraperitoneal… compared with standard treatment (moderate certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.76 [0.55, 1.06]
  2 studies · 101 participants
  Moderate

Prosthetic mesh placement vs usual care

Prosthetic mesh placement may leads to lower incidence of parastomal hernia (worst‐case scenario sensitivity… compared with standard treatment (low certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.49 [0.3, 0.81]
  10 studies · 835 participants
  Low

Prosthetic mesh placement vs usual care

Prosthetic mesh placement may leads to lower incidence of parastomal hernia (best‐case scenario sensitivity… compared with standard treatment (low certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.4 [0.26, 0.61]
  10 studies · 835 participants
  Low

Prosthetic mesh placement vs usual care

Prosthetic mesh placement showed no clear difference in reoperation rate ( compared with standard treatment (low certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.9 [0.5, 1.64]
  9 studies · 757 participants
  Low

Prosthetic mesh placement vs usual care

Prosthetic mesh placement showed no clear difference in operative time for index procedure ( compared with standard treatment (low certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 671 participants
  Low

Prosthetic mesh placement vs usual care

Prosthetic mesh placement showed no clear difference in postoperative length of stay ( compared with standard treatment (moderate certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 500 participants
  Moderate

Prosthetic mesh placement vs usual care

Prosthetic mesh placement showed no clear difference in stoma‐related infection ( compared with standard treatment (low certainty).

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  RR 0.89 [0.32, 2.5]
  6 studies · 472 participants
  Low

Prosthetic mesh placement vs usual care

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 128 participants
  GRADE not reported

Prosthetic mesh placement vs usual care

• Prosthetic mesh placement for the prevention of parastomal herniation 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 263 participants
  GRADE not reported