Findings

What do systematic reviews say?

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

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No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Morphine vs methadone

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 147 participants
Low

Morphine vs buprenorphine

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 113 participants
Moderate

Morphine vs buprenorphine

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 112 participants
Moderate

Morphine vs dilute tincture of opium

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Low

Morphine vs dilute tincture of opium

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Low

Opioids vs clonidine

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Low

Opioids vs clonidine

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Low

Opioids vs diazepam

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low

Opioids vs diazepam

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Very low

Opioids vs phenobarbital

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 166 participants
Low

Opioids vs phenobarbital

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 349 participants
Low

Opioids vs Placebo, no intervention or usual care (with or without placebo)

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Very low

Opioids vs chlorpromazine

Length of hospital stay · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs chlorpromazine

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 76 participants
Low

Opioids vs Placebo, no intervention or usual care (with or without placebo)

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Very low

Aspirin vs placebo

Graft thrombosis (up to 18 months) · people with ESRD receiving haemodialysis through an arteriovenous fistula or graft

Aspirin showed no clear difference in graft thrombosis (28 days to 18 months) compared with placebo (low certainty).

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
OR 0.4 [0.07, 2.25]
3 studies · 175 participants
Low

Clopidogrel vs placebo

Fistula thrombosis (42 days to 6 months) · people with ESRD receiving haemodialysis through an arteriovenous fistula

Clopidogrel showed no clear difference in fistula thrombosis (42 days to 6 months) compared with placebo (moderate certainty).

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
OR 0.4 [0.13, 1.19]
2 studies · 959 participants
Moderate

Clopidogrel vs placebo

Number of related surgical or radiological interventions · people with ESRD receiving haemodialysis through an arteriovenous fistula

Clopidogrel showed no clear difference in number of related surgical or radiological interventions (42 days) compared with placebo (moderate certainty).

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
OR 0.69 [0.26, 1.82]
1 study · 866 participants
Moderate

Aspirin vs placebo

Complications (28 days to 18 months) · people with ESRD receiving haemodialysis through an arteriovenous fistula or graft

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 175 participants
Low

Early discharge vs standard discharge

Infants readmitted for neonatal morbidity within 28 days · healthy mothers and term infants

Early discharge probably leads to higher infants readmitted for neonatal morbidity within 28 days compared with standard discharge (moderate certainty).

1 finding from 1 review

Early postnatal discharge from hospital for healthy mothers and term infants 2021 · Cochrane Headline outcomes only
RR 1.59 [1.27, 1.98]
10 studies · 6918 participants
Moderate