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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Review versions

264 questions in 10 reviews · Other oral health

current versions

No studies 45 · 17%Ungraded 127 · 48.1%Very low 24 · 9.1%Low 46 · 17.4%Moderate 13 · 4.9%High 9 · 3.4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Topical thalidomide vs Another topical agent or placebo Duration to heal oral ulcerations after initiation of treatment · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers Topical treatments for HIV‐related oral ulcers (2012) · Cochrane	No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…	0 studies	No studies
Cognitive behavioural (group psychotherapy) therapy vs Placebo pill Improvement in burning mouth symptoms · Adults over 18 years of age with chronic orofacial pain (burning mouth syndrome) · Not specified Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	RR 1.77 [0.98, 3.21]	1 study	Ungraded
Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs Usual care (conservative treatment: education, counselling, intraoral flat plane appliance) Pain intensity (long term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Long term (more than 3 months) Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD -0.34 [-0.50, -0.18]	7 studies · 658 participants	Ungraded
Habit reversal vs Waiting list control Life interference · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Short term (post-treatment) Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD -0.86 [-1.79, 0.06]	1 study	Ungraded
Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs Usual care (conservative treatment: education, counselling, intraoral flat plane appliance) Muscle palpation pain (long term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Long term (more than 3 months) Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	Muscle palpation pain long term (greater than 3 months): 3 studies; results not pooled owing to substantial heterogeneity (I2=64%); insufficient evidence to draw conclusions for any individual intervention. One study…	3 studies	Ungraded
Hypnosis vs Relaxation Pain intensity (short term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Short term Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	MD -1.84 [-3.26, -0.42]	2 studies · 81 participants	Ungraded
Habit reversal vs Waiting list control Pain intensity (short term / post-treatment) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Short term (post-treatment) Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD -1.31 [-1.97, -0.65]	1 study	Ungraded
Hypnosis vs Relaxation Depression (short term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Short term Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD -0.49 [-0.93, -0.04]	2 studies · 81 participants	Ungraded
Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs Usual care (conservative treatment: education, counselling, intraoral flat plane appliance) Depression (long term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Long term (more than 3 months) Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD -0.35 [-0.54, -0.16]	6 studies · 455 participants	Ungraded
Hypnosis vs Relaxation Anxiety (short term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Short term Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD -0.42 [-0.86, 0.02]	2 studies · 81 participants	Ungraded
Cognitive (behavioural) therapy vs Attention placebo Burning mouth pain intensity (6-month follow-up) · Adults over 18 years of age with chronic orofacial pain (burning mouth syndrome) · Long term (6-month follow-up) Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD -2.79 [-3.83, -1.75]	1 study	Ungraded
Cognitive (behavioural) therapy vs Attention placebo Burning mouth pain intensity (post-treatment) · Adults over 18 years of age with chronic orofacial pain (burning mouth syndrome) · Short term (post-treatment) Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD -2.40 [-3.40, -1.40]	1 study	Ungraded
Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs Usual care (conservative treatment: education, counselling, intraoral flat plane appliance) Pain intensity (short term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Short term (3 months or less), Combination CBT/biofeedback Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD 0.46 [0.02, 0.90]	2 studies · 90 participants	Ungraded
Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs Usual care (conservative treatment: education, counselling, intraoral flat plane appliance) Pain severity - impact: activity interference / disability (long term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD)) · Long term (more than 3 months), CBT alone Psychosocial interventions for the management of chronic orofacial pain (2011) · Cochrane	SMD -0.27 [-0.51, -0.03]	4 studies · 285 participants	Ungraded