Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

331 questions · 336 findings · 74 reviews · Pregnancy and Childbirth

No studies found 102 · 30.4%GRADE not reported 30 · 8.9%Very low 76 · 22.6%Low 92 · 27.4%Moderate 31 · 9.2%High 5 · 1.5%

Oral misoprostol vs vaginal misoprostol

Admission to neonatal intensive care unit · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in admission to neonatal intensive care unit compared with vaginal misoprostol (moderate certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Composite outcome: symptoms of leg cramps (intensity and frequency) Complete recovery: no leg cramps after treatment · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes composite outcome: symptoms of leg cramps (intensity and frequency)… compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Intensity of pain during treatment: mean total scale points The degree of pain was noted in the form, on a scale from 0 to 4 measured over 4 days and nights (0 = no pain, 1 = light pain, 2 = medium pain, 3=strong pain, 4=extreme pain) · treating leg cramps in pregnancy
1 finding from 1 review

Oral magnesium vs placebo/no treatment

At least 50% reduction in pain · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes intensity of pain: 50% reduction in pain score 100‐mm visual… compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Composite outcome: symptoms of leg cramps (intensity and frequency) Partial improvement: decrease in intensity and frequency · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes composite outcome: symptoms of leg cramps (intensity and frequency)… compared with placebo/no treatment (very low certainty).

1 finding from 1 review