First‐line thiazides vs beta‐blocker
- First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes onlyno estimate extracted5 studies · 18501 participantsModerate
First‐line thiazides showed no clear difference in total mortality Duration: 1 to 5 years compared with first‐line calcium channel blockers (moderate certainty).
First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty).
Aspirin showed no clear difference in total mortality compared with placebo (low certainty).
Aspirin showed no clear difference in cardiovascular mortality compared with placebo (low certainty).
Aspirin may leads to lower non‐fatal cardiovascular events compared with placebo (low certainty).
Aspirin leads to higher major bleedinga compared with placebo (high certainty).
Aspirin may leads to lower all cardiovascular events compared with placebo (low certainty).
CCBs showed no clear difference in all‐cause mortality compared with diuretic (moderate certainty).
CCBs may leads to lower cardiovascular mortality compared with β‐blocker (low certainty).
CCBs showed no clear difference in all‐cause mortality compared with ACE inhibitor (low certainty).
CCBs showed no clear difference in myocardial infarction compared with ACE inhibitor (low certainty).
CCBs may leads to lower stroke compared with ACE inhibitor (low certainty).
CCBs may leads to higher congestive heart failure compared with ACE inhibitor (low certainty).
CCBs showed no clear difference in cardiovascular mortality compared with ACE inhibitor (moderate certainty).
CCBs showed no clear difference in all‐cause mortality compared with ARB (moderate certainty).
CCBs probably leads to lower myocardial infarction compared with ARB (moderate certainty).
CCBs showed no clear difference in stroke compared with ARB (moderate certainty).
CCBs may leads to higher congestive heart failure compared with ARB (low certainty).
CCBs showed no clear difference in myocardial infarction compared with diuretic (moderate certainty).