Findings

What do systematic reviews say?

233 questions · 242 findings · 7 reviews · Dental caries

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No studies found 13 · 5.4%GRADE not reported 164 · 67.8%Very low 32 · 13.2%Low 24 · 9.9%Moderate 9 · 3.7%High 0 · 0%

Calcium hydroxide cement (Dycal) vs Calcium sulphate hemihydrate (DentoGen)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether calcium hydroxide cement (Dycal) changes clinical failure compared with calcium sulphate hemihydrate (DentoGen) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 4.00 [0.49, 32.72]
1 study · 40 participants
Very low

Zinc oxide and eugenol (ZOE) vs ZOE + calcium hydroxide + iodoform (MPRCF, unnamed product)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Zinc oxide and eugenol (ZOE) led to lower clinical failure compared with ZOE + calcium hydroxide + iodoform (unnamed product); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.05 [0.00, 0.76]
1 study · 109 participants
GRADE not reported

Calcium hydroxide (CH) vs Portland cement (PC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide (CH) led to higher radiological failure compared with portland cement (PC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 17.00 [1.07, 270.41]
1 study · 30 participants
GRADE not reported

Biodentine vs Propolis

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Biodentine showed no clear difference in radiological failure compared with propolis; GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.43 [0.12, 1.47]
1 study · 50 participants
GRADE not reported

Acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
up to 24 months
No clinical failure in any participant (Demir 2007); not estimable (direct pulp capping)
1 study · 40 participants
GRADE not reported

Vitapex (calcium hydroxide/iodoform) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.83 [0.80, 4.19]
1 study · 50 participants
GRADE not reported

Endoflas (CH + ZOE + iodoform) vs Zinc oxide and eugenol (ZOE)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Endoflas (CH + ZOE + iodoform) showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE) (moderate certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.26 [0.05, 1.50]
2 studies · 80 participants
Moderate

OrthoMTA vs RetroMTA

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

OrthoMTA showed no clear difference in radiological failure compared with retroMTA; GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.70 [0.12, 3.98]
1 study · 96 participants
GRADE not reported

Portland cement (PC) vs Portland cement + iodoform or Portland cement + zirconium oxide

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
up to 24 months
No events in any participant; not estimable
1 study · 30 participants
GRADE not reported

Metapex (calcium hydroxide/iodoform) vs Endoflas chlorophenol free (Endoflas-CF)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with endoflas chlorophenol free (Endoflas-CF); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.00 [0.16, 6.25]
1 study · 32 participants
GRADE not reported

3Mix (ciprofloxacin + metronidazole + minocycline) vs 3Mixtatin

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) may leads to higher clinical failure compared with 3Mixtatin (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 4.00 [1.22, 13.11]
1 study · 160 participants
Low

Diode laser + mineral trioxide aggregate (MTA) vs Formocresol (FC) + zinc oxide and eugenol (ZOE)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
mean 15.7 months
No clinical failure in any participant (Saltzman 2005); not estimable
1 study · 52 participants
GRADE not reported

Metapex (calcium hydroxide/iodoform) vs Full strength formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide/iodoform (CH/iodoform) led to higher clinical failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 9.11 [3.04, 27.31]
1 study · 67 participants
GRADE not reported

Portland cement (PC) vs EMD (enamel matrix derivative) alone

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Portland cement (PC) showed no clear difference in clinical failure compared with enamel matrix derivative (EMD); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6, 12 and 24 months
RR 0.67 [0.12, 3.75]
1 study · 70 participants
GRADE not reported

Vitapex (calcium hydroxide/iodoform) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.00 [0.07, 15.12]
1 study · 50 participants
GRADE not reported

Metapex (calcium hydroxide/iodoform) vs Endoflas (CH + ZOE + iodoform)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with endoflas (CH + ZOE + iodoform); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.33 [0.01, 7.58]
2 studies · 92 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Sodium hypochlorite (NaOCl)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) showed no clear difference in radiological failure compared with sodium hypochlorite (NaOCl); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.33 [0.04, 2.99]
1 study · 50 participants
GRADE not reported

Tempophore vs Mineral trioxide aggregate (MTA)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Tempophore showed no clear difference in clinical failure compared with mineral trioxide aggregate (MTA); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 3.21 [0.14, 75.68]
1 study · 56 participants
GRADE not reported

Electrosurgery vs Formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Electrosurgery showed no clear difference in clinical failure compared with formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
9 months
RR 3.00 [0.13, 71.22]
1 study · 70 participants
GRADE not reported

Vitapex (calcium hydroxide/iodoform) vs ZOE + calcium hydroxide + iodoform (MPRCF, unnamed product)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) led to higher radiological failure compared with ZOE + calcium hydroxide + iodoform (MPRCF, unnamed product); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 42.63 [2.65, 685.54]
1 study · 109 participants
GRADE not reported