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What do systematic reviews say?

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Evidence found and GRADE certainty

122 questions · 126 findings · 21 reviews · Headline outcomes only

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No studies found 23 · 18.3%GRADE not reported 1 · 0.8%Very low 26 · 20.6%Low 44 · 34.9%Moderate 30 · 23.8%High 2 · 1.6%

Intervention not reported

Comparison (intervention vs comparator) · children with myopia (nearsightedness)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects · children with myopia (nearsightedness)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Multifocal vs single vision lens spectacles · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Peripheral plus spectacles vs single vision lens spectacles · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Bifocal vs single vision soft contact lenses · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Rigid gas permeable contact lenses vs spectacles or soft contact lenses · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Orthokeratology contact lenses vs single vision lenses · children with myopia (nearsightedness)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Spherical aberration soft contact lenses vs single vision soft contact lenses · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Antimuscarinic agents vs placebo · children with myopia (nearsightedness)
1 finding from 1 review

Omega‐3 vs placebo

Change in visual loss associated with PSR: visual loss is defined by the deterioration of visual acuity of 3 lines or more with the Snellen chart · people with AMD

Omega 3 fatty acids probably leads to higher loss of 3 or more lines of VA at 24 months compared with placebo (moderate certainty).

2 findings from 1 review

Extended peginterferon plus ribavirin treatment for 72 weeks vs standard peginterferon plus ribavirin treatment

Sustained virological response · participants with detectable HCV RNA after 12 weeks of treatment with pegylated interferon and ribavirin, but with >= 2 log viral…

It is very uncertain whether extended peginterferon plus ribavirin treatment for 72 weeks changes sustained virological response (SVR) compared with standard peginterferon plus ribavirin treatment (very low certainty).

1 finding from 1 review

Extended peginterferon plus ribavirin treatment for 72 weeks vs standard peginterferon plus ribavirin treatment

Relapse · participants with detectable HCV RNA after 12 weeks of treatment with pegylated interferon and ribavirin, but with >= 2 log viral…

It is very uncertain whether extended peginterferon plus ribavirin treatment for 72 weeks changes relapse compared with standard peginterferon plus ribavirin treatment (very low certainty).

1 finding from 1 review

Extended peginterferon plus ribavirin treatment for 72 weeks vs standard peginterferon plus ribavirin treatment

End of treatment response (ETR) · participants with detectable HCV RNA after 12 weeks of treatment with pegylated interferon and ribavirin, but with >= 2 log viral…

It is very uncertain whether extended peginterferon plus ribavirin treatment for 72 weeks changes end of treatment response (ETR) compared with standard peginterferon plus ribavirin treatment (very low certainty).

1 finding from 1 review

Extended peginterferon plus ribavirin treatment for 72 weeks vs standard peginterferon plus ribavirin treatment

Sustained virological response · participants with detectable HCV RNA after four weeks of treatment with pegylated interferon and ribavirin

Extended peginterferon plus ribavirin treatment for 72 weeks may leads to higher sustained virological response (SVR) compared with standard peginterferon plus ribavirin treatment (low certainty).

1 finding from 1 review

Extended peginterferon plus ribavirin treatment for 72 weeks vs standard peginterferon plus ribavirin treatment

Relapse · participants with detectable HCV RNA after four weeks of treatment with pegylated interferon and ribavirin

Extended peginterferon plus ribavirin treatment for 72 weeks may leads to lower relapse rate compared with standard peginterferon plus ribavirin treatment (low certainty).

1 finding from 1 review