Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

138 questions · 142 findings · 24 reviews

No studies found 28 · 19.7%GRADE not reported 7 · 4.9%Very low 31 · 21.8%Low 44 · 31%Moderate 30 · 21.1%High 2 · 1.4%

Lutein with or without zeaxanthin vs placebo

Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo (low certainty).

1 finding from 1 review

Iridotomy vs no iridotomy

Need for additional surgery: proportion of participants who received additional surgery to control IOP at 1 year · people with primary angle‐closure suspect

Iridotomy showed no clear difference in need for additional surgery: proportion of participants who received… compared with no iridotomy (low certainty).

1 finding from 1 review

Intervention not reported

Undercorrected vs fully corrected spectacles · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Systemic 7‐methylxanthine vs placebo · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Atropine plus multifocal spectacles vs placebo plus SVLs · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Atropine plus bifocal spectacles vs cyclopentolate plus SVLs · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Bifocal spectacles vs SVLs with timolol drops · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Tropicamide plus bifocal spectacles vs SVLs · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Comparison (intervention vs comparator) · children with myopia (nearsightedness)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects · children with myopia (nearsightedness)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Multifocal vs single vision lens spectacles · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Peripheral plus spectacles vs single vision lens spectacles · children with myopia (nearsightedness)
1 finding from 1 review