Findings

What do systematic reviews say?

145 questions · 148 findings · 8 reviews

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No studies found 26 · 17.6%GRADE not reported 74 · 50%Very low 17 · 11.5%Low 24 · 16.2%Moderate 7 · 4.7%High 0 · 0%

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy vs 3Mix pulpectomy

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in radiological failure compared with 3Mix pulpectomy; GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 11.00 [0.64, 190.53]
1 study · 60 participants
GRADE not reported

Vitapex (calcium hydroxide/iodoform) vs Sealapex (eugenol-free calcium hydroxide)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with sealapex (eugenol-free calcium hydroxide); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 0.20 [0.01, 3.92]
1 study · 40 participants
GRADE not reported

Metapex (calcium hydroxide/iodoform) vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide/iodoform (CH/iodoform) showed no clear difference in radiological failure compared with calcium hydroxide (CH); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.17 [0.87, 1.59]
1 study · 65 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs simvastatin

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
No radiological failure in any participant; not estimable
1 study · 160 participants
GRADE not reported

3Mixtatin vs simvastatin

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
No radiological failure in any participant; not estimable
1 study · 160 participants
GRADE not reported

Glutaraldehyde + zinc oxide and eugenol (ZOE) vs Full strength formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + zinc oxide and eugenol (ZOE) showed no clear difference in radiological failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
3 months
RR 0.46 [0.09, 2.28]
1 study · 48 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs 3Mix (ciprofloxacin + metronidazole + minocycline)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
No radiological failure in any participant (Aminabadi 2016); not estimable
1 study · 160 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Calcium hydroxide + sodium hypochlorite (NaOCl)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) showed no clear difference in radiological failure compared with calcium hydroxide + sodium hypochlorite (NaOCl); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.09 [0.01, 1.58]
1 study · 62 participants
GRADE not reported

Electrosurgery vs Calcium-enriched mixture (CEM)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Electrosurgery showed no clear difference in radiological failure compared with calcium-enriched mixture (CEM); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.50 [0.10, 2.61]
1 study · 102 participants
GRADE not reported

Calcium hydroxide (CH) vs Mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide (CH) led to higher radiological failure compared with mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 8.00 [1.06, 60.21]
1 study · 62 participants
GRADE not reported

Electrofulguration + calcium hydroxide (CH) vs Electrofulguration + zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Electrofulguration + calcium hydroxide (CH) showed no clear difference in radiological failure compared with electrofulguration + zinc oxide and eugenol (ZOE); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.94 [0.47, 1.88]
1 study · 47 participants
GRADE not reported

Erbium:YAG laser vs Formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Erbium:YAG laser showed no clear difference in radiological failure compared with formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 1.06 [0.28, 4.01]
1 study · 97 participants
GRADE not reported

Calcium hydroxide (CH) vs Zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide (CH) showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 2.50 [0.50, 12.50]
2 studies · 110 participants
Low

Endoflas (CH + ZOE + iodoform) vs Zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Endoflas (CH + ZOE + iodoform) showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE) (moderate certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.26 [0.05, 1.50]
2 studies · 80 participants
Moderate

Metapex (calcium hydroxide/iodoform) vs Zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE) (moderate certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.00 [0.31, 3.27]
2 studies · 62 participants
Moderate

Metapex (calcium hydroxide/iodoform) vs Zinc oxide and propolis (ZOP)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with zinc oxide and propolis (ZOP); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.80 [0.26, 2.45]
1 study · 32 participants
GRADE not reported

Acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
up to 24 months
No radiological failure in any participant; not estimable
1 study · 40 participants
GRADE not reported

Sealapex (eugenol-free calcium hydroxide) vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Sealapex (eugenol-free calcium hydroxide) showed no clear difference in radiological failure compared with calcium hydroxide (CH); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 0.50 [0.10, 2.43]
1 study · 40 participants
GRADE not reported

Low‐level laser therapy vs Formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Low-level laser therapy (LLLT) showed no clear difference in radiological failure compared with formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 7.00 [0.39, 124.83]
1 study · 30 participants
GRADE not reported

Aloe vera vs Mineral trioxide aggregate (MTA)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Aloe vera led to higher radiological failure compared with mineral trioxide aggregate (MTA); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 28.00 [4.07, 192.79]
1 study · 60 participants
GRADE not reported