Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

306 questions · 324 findings · 26 reviews

No studies found 59 · 18.2%GRADE not reported 30 · 9.3%Very low 91 · 28.1%Low 62 · 19.1%Moderate 78 · 24.1%High 4 · 1.2%

RISPERIDONE DEPOT vs ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE)

Adverse events: Any prolactin‐related ‐ medium term · patients with schizophrenia

RISPERIDONE DEPOT showed no clear difference in adverse events: Any prolactin‐related ‐ medium term compared with ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE) (moderate certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE)

Adverse events: Any glucose‐related ‐ medium/long term · patients with schizophrenia

RISPERIDONE DEPOT showed no clear difference in adverse events: Any glucose‐related ‐ medium/long term compared with ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE) (low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs PLACEBO + CLOZAPINE

Mental state: No 20% response (as defined by PANSS/BPRS total change) · patients with schizophrenia

RISPERIDONE + CLOZAPINE showed no clear difference in mental state: no clinically significant response in psychotic… compared with PLACEBO + CLOZAPINE (low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs PLACEBO + CLOZAPINE

Global state: 2. no significant clinical improvement ‐ CGI, short term (up to 12 weeks) · patients with schizophrenia

RISPERIDONE + CLOZAPINE showed no clear difference in global state: no significant clinical improvement ‐ CGI short term compared with PLACEBO + CLOZAPINE (low certainty).

1 finding from 1 review