Findings

What do systematic reviews say?

107 questions · 109 findings · 10 reviews · Gynaecology and Fertility

No studies found 17 · 15.6%GRADE not reported 9 · 8.3%Very low 24 · 22%Low 41 · 37.6%Moderate 14 · 12.8%High 4 · 3.7%

Abnormal uterine bleeding: change in menstrual blood loss · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 310 participants
Moderate

Abnormal uterine bleeding: amenorrhoea · women with uterine fibroids

SPRM probably leads to higher abnormal uterine bleeding: amenorrhoea compared with placebo (moderate certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 82.5 [37.1, 183.9]
7 studies · 590 participants
Moderate

Pelvic pain · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 629 participants
GRADE not reported

Adverse effects: SPRM‐associated endometrial changes · women with uterine fibroids

SPRM may leads to higher adverse effects: SPRM‐associated endometrial changes compared with placebo (low certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 15.12 [6.45, 35.47]
5 studies · 405 participants
Low

Quality of life: change in symptom severity score · uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 281 participants
Moderate

Quality of life: change in health‐related quality of life score · uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 281 participants
Moderate

Abnormal uterine bleeding: change in menstrual blood loss · uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 281 participants
Low