All‐cause mortality · pulmonary arterial hypertension
Group 1 Pulmonary arterial hypertension ‐ PDE5i showed no clear difference in mortality compared with ERA (moderate certainty).
1 finding from 1 review
Quality of life Kansas City Cardiomyopathy Quality‐of‐Life questionnaire (higher scores indicate better quality of life) · pulmonary arterial hypertension
1 finding from 1 review
Six‐minute walk distance · pulmonary arterial hypertension
1 finding from 1 review
PAP · pulmonary arterial hypertension
1 finding from 1 review
RAP · pulmonary arterial hypertension
1 finding from 1 review
Cardiac index · pulmonary arterial hypertension
1 finding from 1 review
PVR · pulmonary arterial hypertension
1 finding from 1 review
All‐cause mortality · pulmonary arterial hypertension
Group 1 Pulmonary arterial hypertension ‐ PDE5i leads to lower mortality compared with placebo (high certainty).
1 finding from 1 review
QoL · pulmonary arterial hypertension
1 finding from 1 review
PAP · pulmonary arterial hypertension
1 finding from 1 review
RAP · pulmonary arterial hypertension
1 finding from 1 review
Cardiac index · pulmonary arterial hypertension
1 finding from 1 review
PVR · pulmonary arterial hypertension
1 finding from 1 review
Improvement in WHO functional class · pulmonary arterial hypertension
Group 1 Pulmonary arterial hypertension ‐ PDE5i showed no clear difference in improvement in WHO functional class compared with placebo, on combination therapy (moderate certainty).
1 finding from 1 review
Improvement in WHO functional class · people with pulmonary hypertension group 2 ‐ 4
Mixed Pulmonary hypertension group 2 ‐ 4 ‐ PDE5i probably leads to higher improvement in WHO functional class compared with placebo (moderate certainty).
1 finding from 1 review
Six‐minute walk distance · people with pulmonary hypertension group 2 ‐ 4
1 finding from 1 review
All‐cause mortality · people with pulmonary hypertension group 2 ‐ 4
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · people with pulmonary hypertension group 2 ‐ 4
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
PASP · people with pulmonary hypertension group 2 ‐ 4
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found no difference in pulpotomy success between MTA and platelet-rich fibrin (both 100% through 24 months; not pooled; ungraded).
1 finding from 1 review
Single RCT (Keswani 2014, 62 teeth): 100% clinical and radiographic success in both MTA and PRF at 6, 12 and 24 months (MTA 29/29, 27/27, 26/26; PRF 30/30, 29/29, 27/27); no difference between groups; not pooled
1 study · 62 participants
GRADE not reported