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Evidence found and GRADE certainty

265 questions · 283 findings · 18 reviews · Skin

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No studies found 59 · 20.8%GRADE not reported 20 · 7.1%Very low 45 · 15.9%Low 58 · 20.5%Moderate 64 · 22.6%High 37 · 13.1%

Topical ivermectin vs topical metronidazole

QoL · Participants with rosacea

Topical ivermectin leads to higher HRQOL DLQI, proportion of participants that reported at end of study… compared with topical metronidazole (high certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Topical ivermectin leads to higher participant‐assessed improvement in rosacea severity Likert scale ‐… compared with topical metronidazole (high certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Proportion of participants with adverse event · Participants with rosacea

Topical ivermectin showed no clear difference in proportion of participants with adverse event compared with topical metronidazole (moderate certainty).

1 finding from 1 review

Topical ivermectin vs topical metronidazole

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Topical ivermectin leads to higher physician‐assessed improvement in rosacea severity compared with topical metronidazole (high certainty).

1 finding from 1 review

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in participant‐assessed improvement in rosacea severity Excellent… compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review