evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

106 questions · 106 findings · 4 reviews · Common Mental Disorders

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 29 · 27.4%GRADE not reported 5 · 4.7%Very low 18 · 17%Low 16 · 15.1%Moderate 25 · 23.6%High 13 · 12.3%

Valproate vs lithium

Dropout · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in dropout rate ‐ All‐cause At 2‐4 weeks (secondary acceptability… compared with lithium (moderate certainty).

1 finding from 1 review

Valproate vs lithium

Response rate at 8 weeks (primary efficacy outcome) · Children and adolescents with acute mania

It is very uncertain whether valproate changes response rate at 8 weeks (primary efficacy outcome) compared with lithium (very low certainty).

1 finding from 1 review

Valproate vs lithium

Number of participants with any adverse event (primary tolerability outcome) · Children and adolescents with acute mania

The review found no eligible studies for this question.

1 finding from 1 review

Valproate vs lithium

Adverse events: somnolence/sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 8 weeks (secondary… compared with lithium (very low certainty).

1 finding from 1 review

Valproate vs lithium

Change in symptom severity of mania rating scale at 8 weeks (secondary efficacy outcome) · Children and adolescents with acute mania
1 finding from 1 review

Valproate vs lithium

Dropout · Children and adolescents with acute mania

It is very uncertain whether valproate changes dropout rate ‐ All‐cause At 8 weeks (secondary acceptability outcome) compared with lithium (very low certainty).

1 finding from 1 review