What do systematic reviews say?

Corticosteroids vs placebo compared

Corticosteroids showed no clear difference in serious adverse events (dichotomous data) ‐ suspected or probable… compared with placebo compared (high certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.44 [0.18, 1.09]
  1 study · 180 participants
  High

Corticosteroids vs placebo compared

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 180 participants
  High

Early physical therapy vs control

Early physical therapy showed no clear difference in occurrence of CIP/CIM ‐ in the total population randomised compared with control (low certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.81 [0.6, 1.08]
  1 study · 104 participants
  Low

Early physical therapy vs control

Early physical therapy probably leads to lower occurrence of CIP/CIM ‐ in screened population compared with control (moderate certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.62 [0.39, 0.96]
  1 study · 82 participants
  Moderate

Early physical therapy vs control

Early physical therapy showed no clear difference in serious adverse events ‐ in total population randomised compared with control (moderate certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 3.36 [0.14, 80.62]
  1 study · 104 participants
  Moderate

Electrical muscle stimulation vs control

It is very uncertain whether electrical muscle stimulation changes occurrence of CIP/CIM ‐ in the total population randomised compared with control (very low certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.94 [0.78, 1.15]
  1 study · 140 participants
  Very low

Electrical muscle stimulation vs control

It is very uncertain whether electrical muscle stimulation changes occurrence of CIP/CIM ‐ in screened population compared with control (very low certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.32 [0.1, 1.01]
  1 study · 52 participants
  Very low

Intensive insulin therapy vs conventional insulin therapy

Intensive insulin therapy probably leads to lower occurrence of CIP/CIM ‐ in screened population compared with conventional insulin therapy (moderate certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.65 [0.55, 0.77]
  2 studies · 825 participants
  Moderate

Intensive insulin therapy vs conventional insulin therapy

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2748 participants
  High

Intensive insulin therapy vs conventional insulin therapy

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2748 participants
  High

Intensive insulin therapy vs conventional insulin therapy

Intensive insulin therapy showed no clear difference in death ‐ at 30 days after ICU admission, in total population randomised compared with conventional insulin therapy (high certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.94 [0.8, 1.1]
  2 studies · 2748 participants
  High

Intensive insulin therapy vs conventional insulin therapy

Intensive insulin therapy showed no clear difference in death ‐ at 180 days after ICU admission, in total population… compared with conventional insulin therapy (moderate certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.87 [0.76, 1]
  2 studies · 2748 participants
  Moderate

Intensive insulin therapy vs conventional insulin therapy

Intensive insulin therapy leads to higher serious adverse events, ‐ in total population randomised ‐… compared with conventional insulin therapy (high certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 6.27 [4.15, 9.49]
  2 studies · 2748 participants
  High

Corticosteroids vs placebo compared

Corticosteroids showed no clear difference in occurrence of CIP/CIM ‐ in total population randomised compared with placebo compared (low certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 1.27 [0.77, 2.08]
  1 study · 180 participants
  Low

Corticosteroids vs placebo compared

Corticosteroids showed no clear difference in occurrence of CIP/CIM ‐ in screened population compared with placebo compared (moderate certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 1.09 [0.53, 2.26]
  1 study · 92 participants
  Moderate

Amantadine vs placebo

Amantadine showed no clear difference in reduction in fatigue of at least 1‐point on the Fatigue Severity… compared with placebo (low certainty).

• Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
  OR 0.56 [0.22, 1.35]
  74 participants
  Low

Ascorbic acid vs placebo

• Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 406 participants
  Moderate

Ascorbic acid vs placebo

• Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 224 participants
  Moderate

Ascorbic acid vs placebo

• Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 400 participants
  Moderate

Ascorbic acid vs placebo

The review found no eligible studies for this question.

• Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found