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What do systematic reviews say?

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Evidence found and GRADE certainty

104 questions · 107 findings · 10 reviews · Oral medicine and oral cancer

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No studies found 10 · 9.3%GRADE not reported 77 · 72%Very low 19 · 17.8%Low 1 · 0.9%Moderate 0 · 0%High 0 · 0%

Systemic oral acyclovir vs placebo or no treatment

Number of individuals with eating difficulties (8 days after administration); duration of eating difficulties · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals with eating difficulties (8 days after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Systemic oral acyclovir vs placebo or no treatment

Difficulty in drinking (number with drinking difficulties) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals with drinking difficulties (8 days after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Length of hospital stay · Patients with cancer receiving chemotherapy and/or radiotherapy

The review found no eligible studies for this question.

1 finding from 1 review