What do systematic reviews say?

Intratympanic corticosteroids vs systemic corticosteroids

Intratympanic corticosteroids probably leads to higher ear pain: timing not reportedf compared with systemic corticosteroids (moderate certainty).

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  RR 15.68 [6.22, 39.49]
  2 studies · 289 participants
  Moderate

Intratympanic corticosteroids vs systemic corticosteroids

• Intratympanic corticosteroids for sudden sensorineural hearing loss 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 393 participants
  Low

Intramuscular corticosteroids vs oral corticosteroid

Intramuscular corticosteroids showed no clear difference in relapse compared with oral corticosteroids (low certainty).

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.94 [0.72, 1.24]
  9 studies · 804 participants
  Low
• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.74 [0.51, 1.07]
  7 studies · 742 participants
  Moderate
• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.99 [0.74, 1.33]
  5 studies · 556 participants
  Low

Intramuscular corticosteroids vs oral corticosteroid

Intramuscular corticosteroids showed no clear difference in adverse events compared with oral corticosteroids (low certainty).

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.83 [0.64, 1.07]
  5 studies · 404 participants
  Low

Intramuscular corticosteroids vs oral corticosteroid

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 272 participants
  Moderate

Intramuscular corticosteroids vs oral corticosteroid

Intramuscular corticosteroids showed no clear difference in symptom persistence compared with oral corticosteroids (low certainty).

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.41 [0.14, 1.2]
  3 studies · 80 participants
  Low

Intramuscular corticosteroids vs oral corticosteroid

Intramuscular corticosteroids showed no clear difference in 24‐hour beta agonist use compared with oral corticosteroids (low certainty).

• Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for… 2018 · Cochrane Headline outcomes only
  RR 0.54 [0.21, 1.37]
  2 studies · 48 participants
  Low

Mild/moderate topical corticosteroids vs no topical corticosteroids

Mild/moderate topical corticosteroids may leads to lower low birth weight compared with no topical corticosteroids (low certainty).

• Safety of topical corticosteroids in pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.9
  55713 participants
  Low

Mild/moderate topical corticosteroids vs no topical corticosteroids

Mild/moderate topical corticosteroids may leads to lower preterm delivery compared with no topical corticosteroids (low certainty).

• Safety of topical corticosteroids in pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.88
  55713 participants
  Low

Mild/moderate topical corticosteroids vs no topical corticosteroids

Mild/moderate topical corticosteroids may leads to lower foetal death compared with no topical corticosteroids (low certainty).

• Safety of topical corticosteroids in pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.7
  48749 participants
  Low

Mild/moderate topical corticosteroids vs no topical corticosteroids

Mild/moderate topical corticosteroids may leads to lower low Apgar score compared with no topical corticosteroids (low certainty).

• Safety of topical corticosteroids in pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.73
  8756 participants
  Low

Mild/moderate topical corticosteroids vs no topical corticosteroids

Mild/moderate topical corticosteroids may leads to lower congenital abnormality compared with no topical corticosteroids (low certainty).

• Safety of topical corticosteroids in pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.93
  9263 participants
  Low

Mild/moderate topical corticosteroids vs no topical corticosteroids

Mild/moderate topical corticosteroids may leads to lower orofacial cleft compared with no topical corticosteroids (low certainty).

• Safety of topical corticosteroids in pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.95
  38446 participants
  Low

Corticosteroids vs placebo

Corticosteroids may leads to higher clinical improvement (dichotomous) compared with placebo (low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 1.74 [1.08, 2.8]
  6 studies · 583 participants
  Low

Corticosteroids vs placebo

Corticosteroids probably leads to higher histological improvement (dichotomous) compared with placebo (moderate certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 4.58 [1.66, 12.62]
  3 studies · 280 participants
  Moderate

Corticosteroids vs placebo

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 269 participants
  Moderate

Corticosteroids vs placebo

The review found no eligible studies for this question.

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Corticosteroids vs placebo

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 240 participants
  Very low

Corticosteroids vs placebo

Corticosteroids may leads to lower withdrawals due to adverse events 12 to 50 weeks compared with placebo (low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 0.37 [0.16, 0.87]
  3 studies · 280 participants
  Low

Corticosteroids vs placebo

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 475 participants
  Low