What do systematic reviews say?

Albumin and fresh frozen plasma vs crystalloid

Albumin and fresh frozen plasma showed no clear difference in renal replacement therapy compared with crystalloid (low certainty).

• Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
  RR 1.11 [0.96, 1.27]
  2 studies · 3028 participants
  Low

Albumin and fresh frozen plasma vs crystalloid

• Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Starches vs crystalloid

Starches showed no clear difference in all‐cause mortality (within 30 days) compared with crystalloid (moderate certainty).

• Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
  RR 0.99 [0.9, 1.09]
  11 studies · 10135 participants
  Moderate

Starches vs crystalloid

Starches probably leads to higher transfusion of blood products compared with crystalloid (moderate certainty).

• Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
  RR 1.19 [1.02, 1.39]
  8 studies · 1917 participants
  Moderate

Starches vs crystalloid

Starches probably leads to higher renal replacement therapy compared with crystalloid (moderate certainty).

• Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
  RR 1.3 [1.14, 1.48]
  9 studies · 8527 participants
  Moderate

Starches vs crystalloid

• Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Dextrans vs crystalloid

Dextrans showed no clear difference in all‐cause mortality (at end of compared with crystalloid (moderate certainty).

• Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
  RR 0.99 [0.88, 1.11]
  19 studies · 4736 participants
  Moderate

Dextrans vs crystalloid

Dextrans showed no clear difference in all‐cause mortality (within 90 days and within 30 days) compared with crystalloid (moderate certainty).

• Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
  RR 0.99 [0.87, 1.12]
  10 studies · 3353 participants
  Moderate

Dextrans vs crystalloid

It is very uncertain whether dextrans changes transfusion of blood products compared with crystalloid (very low certainty).

• Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
  RR 0.92 [0.77, 1.1]
  3 studies · 1272 participants
  Very low