Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

166 questions · 167 findings · 14 reviews · Schizophrenia

No studies found 34 · 20.4%GRADE not reported 31 · 18.6%Very low 63 · 37.7%Low 30 · 18%Moderate 9 · 5.4%High 0 · 0%

COGNITIVE BEHAVIOUR THERAPY + MOTIVATIONAL INTERVIEWING vs usual care

Adverse event: Death · people with both severe mental illness and substance misuse

Cognitive behavioural therapy + motivational interviewing showed no clear difference in adverse event: Death compared with standard care (low certainty).

1 finding from 1 review

COGNITIVE BEHAVIOUR THERAPY + MOTIVATIONAL INTERVIEWING vs usual care

Relapse · people with both severe mental illness and substance misuse

It is very uncertain whether cognitive behavioural therapy + motivational interviewing changes relapse:* Relapse at 3 months after 9 months of treatment compared with standard care (very low certainty).

1 finding from 1 review