Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

627 questions · 638 findings · 45 reviews

No studies found 89 · 13.9%GRADE not reported 37 · 5.8%Very low 221 · 34.6%Low 181 · 28.4%Moderate 92 · 14.4%High 18 · 2.8%

Antidepressants vs placebo

Acceptability ‐ total dropouts · women of any age, with PND up to 12 months

Antidepressants showed no clear difference in treatment acceptability ‐ dropouts compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Dropout ‐ Studies with low risk of bias · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in dropout ‐ Studies with low risk of bias compared with placebo according to any definition (high certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo according to any definition (low certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Severity of depression dichotomous measures ‐ "very much" or "much" improved on the Clinical Global Impression Scale · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo according to any definition (low certainty).

1 finding from 1 review