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Evidence found and GRADE certainty

1,171 questions · 1,373 findings · 60 reviews · Dental caries

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No studies found 282 · 20.5%GRADE not reported 606 · 44.1%Very low 257 · 18.7%Low 160 · 11.7%Moderate 66 · 4.8%High 2 · 0.1%

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less
1 finding from 1 review

Ceramic inlays (all types) vs Gold inlay

Postoperative sensitivity · Adults who require restorative treatment in posterior teeth
1 finding from 1 review
  • Ceramic inlays for restoring posterior teeth 2003 · Cochrane All outcomes
    1 week
    Postoperative sensitivity was evaluated 1 week after placement. No teeth with ceramic inlays were found to have postoperative sensitivity, while one tooth with gold inlay presented sensitivity, which lasted more than 2…
    1 study · 20 participants
    GRADE not reported

Fluoride toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Acquiring extrinsic tooth staining (adverse effect; stannous fluoride toothpaste) · Children and adolescents aged 16 years or less

Fluoride toothpaste led to higher acquiring extrinsic tooth staining (adverse effect; stannous… compared with placebo (non-fluoride) toothpaste; GRADE not reported.

1 finding from 1 review

Ceramic inlays (all types) vs Gold inlay

Failure rate (longevity) at 5 years · Adults who require restorative treatment in posterior teeth

Ceramic inlays (all types) showed no clear difference in failure rate (longevity) at 5 years compared with gold inlay; GRADE not reported.

1 finding from 1 review

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects: dental fluorosis · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Proportion developing new caries · Children and adolescents aged 16 years or younger (permanent dentition)

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… led to lower proportion of children developing one or more new caries compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Ceramic inlays (all types) vs Composite resin (direct restoration)

Outcome not reported · Adults who require restorative treatment in posterior teeth

The review found no eligible studies for this question.

1 finding from 1 review
  • Ceramic inlays for restoring posterior teeth 2003 · Cochrane All outcomes
    No eligible randomised controlled trial comparing ceramic inlays with composite resin (direct) restorations was identified; this planned comparison could not be evaluated.
    0 studies
    No studies found