Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,266 questions · 1,314 findings · 160 reviews · Headline outcomes only

No studies found 309 · 23.5%GRADE not reported 34 · 2.6%Very low 356 · 27.1%Low 393 · 29.9%Moderate 187 · 14.2%High 35 · 2.7%

SPRM vs placebo

Preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg compared with placebo (low certainty).

1 finding from 1 review

SPRM vs placebo

Preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal acetate 10 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: Reduction in menstrual bleeding (PBAC < 75)… compared with placebo (low certainty).

1 finding from 1 review

Misoprostol vs surgery

Unplanned surgical intervention · incomplete miscarriage

Misoprostol may leads to higher unplanned surgical intervention compared with surgery (low certainty).

1 finding from 1 review

Misoprostol vs surgery

Women's views/acceptability of method · incomplete miscarriage

Misoprostol showed no clear difference in women's views/acceptability of method compared with surgery (moderate certainty).

1 finding from 1 review