Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,340 questions · 1,512 findings · 205 reviews

No studies found 317 · 21%GRADE not reported 358 · 23.7%Very low 356 · 23.5%Low 271 · 17.9%Moderate 173 · 11.4%High 37 · 2.4%

Emergency endovascular aneurysm repair vs conventional open repair

Complication: renal complications (moderate or severe) (30‐day) · people diagnosed with RAAA

Emergency endovascular aneurysm repair showed no clear difference in complication: renal complications (moderate or severe) (30‐day) compared with conventional open repair (low certainty).

1 finding from 1 review

Neuroprotection vs control

Progression of visual field loss (worsening of one or more stages, accordingto the Glaucoma Staging System‐2) (at 12 months) · people with open‐angle glaucoma

It is very uncertain whether neuroprotection changes visual field: the proportion of participants with progression of… compared with control (very low certainty).

1 finding from 1 review

Neuroprotection vs control

Vertical cup‐disc ratio: the proportion of participants with asymmetrical vertical cup‐disc ratio greater than 0.3 at 4 years' · people with open‐angle glaucoma

The review found no eligible studies for this question.

1 finding from 1 review

Neuroprotection vs control

Adverse effects: ocular allergy to the study medication requiring discontinuation up to 4 years' · people with open‐angle glaucoma

It is very uncertain whether neuroprotection changes adverse effects: ocular allergy to the study medication requiring… compared with control (very low certainty).

1 finding from 1 review

Pathogen‐reduced platelets vs standard platelets

Number of participants with 'any bleeding' event(s) (WHO grade 1 to 4 or equivalent) ‐ · thrombocytopenia

Pathogen‐reduced platelets may leads to higher number of participants with 'any bleeding' event(s) (WHO grade 1 to… compared with standard platelets (low certainty).

1 finding from 1 review

Pathogen‐reduced platelets vs standard platelets

Number of participants with 'severe' bleeding event(s) (WHO grade ≥ 3 or equivalent) ‐ · thrombocytopenia

Pathogen‐reduced platelets showed no clear difference in number of participants with 'severe' bleeding event(s) (WHO grade ≥… compared with standard platelets (moderate certainty).

1 finding from 1 review