Participant‐reported pain relief of 50% or greater · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).
1 finding from 1 review
Proportion of patients with >50% maximum pain relief (TOTPAR) over 2 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Combined paracetamol plus ibuprofen in a single tablet (e.g.… showed no clear difference in proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).
1 finding from 1 review
Adverse events · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
1 finding from 1 review
The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
2 studies
GRADE not reported
Participant‐reported pain relief of 50% or greater · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Combined paracetamol plus ibuprofen in a single tablet (e.g.… probably leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).
1 finding from 1 review
Proportion of patients with >50% maximum pain relief (TOTPAR) over 2 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).
1 finding from 1 review
Patients not using rescue medication at 6 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher patients not using rescue medication at 6 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).
1 finding from 1 review
Intervention not reported
At least 50% of maximum pain relief over 4 to 6 hours · Adults with moderate or severe acute postoperative pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Intervention not reported
Participants with at least 1 adverse event · Adults with moderate or severe acute postoperative pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Intervention not reported
Participants with a serious adverse event · Adults with moderate or severe acute postoperative pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Intervention not reported
Deaths · Adults with moderate or severe acute postoperative pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Intervention not reported
Pain free response at 2 h · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Intervention not reported
Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Intervention not reported
Sustained pain‐free at 24 h · adults with migraine headache ‐ moderate or severe pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Sustained headache relief at 24 h · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Intervention not reported
At least one AE · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Intervention not reported
Serious AE · adults with migraine headache ‐ moderate or severe pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Pain free response at 2 h · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Intervention not reported
Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Intervention not reported
Headache relief at 1 h · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Intervention not reported
At least one AE · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review
no estimate extracted
Studies not reported
Low