Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Intranasal steroid spray vs placebo

Adverse event: systemic corticosteroid side effects · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether topical (intranasal) steroids changes adverse event: systemic corticosteroid side effects compared with placebo (very low certainty).

1 finding from 1 review

Intranasal steroid spray vs no treatment

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether topical (intranasal) steroids changes presence/persistence of OME (short‐term); assumed ICC = 0.5 compared with no treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Relapse Defined as MUAC < 115 mm within 2 months after recovery (Hussain 2021) · children aged > 6 months and ≤ 5 years with wasting

The intervention showed no clear difference in relapse Defined as MUAC < 115 mm within 2 months after recovery… (moderate certainty).

1 finding from 1 review

Intervention not reported

Transfer to inpatient care Defined as referral for complications such as fever, pneumonia, anorexia or dehydration (Hussain 2021) · children aged > 6 months and ≤ 5 years with wasting

The intervention showed no clear difference in transfer to inpatient care Defined as referral for complications… (moderate certainty).

1 finding from 1 review