Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Moisturisers vs vehicle, placebo or no moisturiser

Number of participants reporting an adverse event · people with eczema

All moisturisers showed no clear difference in number of participants reporting an adverse event compared with vehicle, placebo or no moisturiser (moderate certainty).

1 finding from 1 review

Vehicle treatment + daily moisturiser vs fluticasone propionate twice weekly + daily moisturiser

Change from baseline in disease severity as assessed by the participants (number of participants reporting good to excellent result) · people with eczema

Vehicle treatment + daily moisturiser leads to lower change from baseline in disease severity as assessed by the… compared with fluticasone propionate twice weekly + daily moisturiser (high certainty).

1 finding from 1 review

Vehicle treatment + daily moisturiser vs fluticasone propionate twice weekly + daily moisturiser

Number of participants reporting an adverse event · people with eczema

Vehicle treatment + daily moisturiser showed no clear difference in number of participants reporting an adverse event compared with fluticasone propionate twice weekly + daily moisturiser (low certainty).

1 finding from 1 review

Vehicle treatment + daily moisturiser vs fluticasone propionate twice weekly + daily moisturiser

Number of participants who experienced a flare · people with eczema

Vehicle treatment + daily moisturiser probably leads to higher number of participants who experienced a flare compared with fluticasone propionate twice weekly + daily moisturiser (moderate certainty).

1 finding from 1 review