Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
Azithromycin + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -3.32 [-6.23, -0.42]
6 studies · 228 participants
GRADE not reported
MD -1.28 [-4.32, 1.76]
2 studies · 110 participants
Very low
MD -3.18 [-7.01, 0.65]
6 studies · 216 participants
GRADE not reported
Physical/verbal resistance and self-reported pain during LA (other studies) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
Hypnosis led to lower physical/verbal resistance and self-reported pain during LA (other… compared with conventional treatment; GRADE not reported.
1 finding from 1 review
Postoperative pain (mean) · Adults with mandibular third molars requiring removal
Triangular flap led to lower postoperative pain (mean) compared with envelope flap; GRADE not reported.
1 finding from 1 review
Reduction in contamination of aerosols on operator's face shield/mask (RCTs) · People undergoing aerosol-generating procedures (AGPs) in a dental setting
High-volume evacuation (HVE) showed no clear difference in reduction in contamination of aerosols on operator's face… compared with no HVE; GRADE not reported.
1 finding from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.38 [0.00, 0.76]
3 studies · 75 participants
GRADE not reported
MD 1.00 [0.30, 1.70]
1 study · 27 participants
Very low
MD -0.16 [-0.56, 0.24]
2 studies · 49 participants
GRADE not reported
Oral health knowledge (1-9 scale) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with risk-based recall showed no clear difference in oral health knowledge (1-9 scale) compared with clinical examination with 24-month recall; GRADE not reported.
1 finding from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Clindamycin + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD -0.14 [-0.82, 0.54]
1 study · 26 participants
GRADE not reported
MD -0.10 [-0.79, 0.59]
1 study · 26 participants
GRADE not reported
MD 0.20 [-0.38, 0.78]
1 study · 26 participants
Very low
Temporary altered tongue sensation · Adults with mandibular third molars requiring removal
Lingual split with chisel showed no clear difference in temporary altered tongue sensation compared with lingual split with bur; GRADE not reported.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis
It is very uncertain whether amoxicillin + clavulanate + SRP changes percentage of bleeding on probing (BOP) compared with SRP (very low certainty).
3 findings from 1 review
MD 0.00 [-0.09, 0.09]
1 study · 21 participants
Very low
MD -0.10 [-0.19, -0.01]
1 study · 21 participants
GRADE not reported
MD -0.10 [-0.19, -0.01]
1 study · 21 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Topical clobetasol propionate showed no clear difference in pain (mean VAS score) compared with topical tacrolimus; GRADE not reported.
1 finding from 1 review
Sensitivity · Extracted molar teeth of adults with resin composite approximal restorations (in vitro; secondary root caries; Switzerland)
1 finding from 1 review
Probing pocket depth · Adults with chronic periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.00 [-0.19, 0.19]
1 study · 21 participants
GRADE not reported
MD 0.10 [-0.17, 0.37]
1 study · 21 participants
Very low
MD 0.20 [-0.02, 0.42]
1 study · 21 participants
GRADE not reported
Progression of dentinal carious lesions into enamel or dentine · Children and adolescents (general population, aged under 20 years)
Resin-modified glass ionomer fissure sealant showed no clear difference in progression of dentinal carious lesions into enamel or dentine compared with fluoride varnish; GRADE not reported.
1 finding from 1 review
Diagnostic accuracy (sensitivity and specificity) for detection of early enamel caries (D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Fluorescence devices for the detection of dental caries 2020 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies)
Analysed as a separate index test (coupled forest plot and SROC plot, Figure 24 / Figure 25; Appendix 5); no summary DOR or sensitivity/specificity point reported numerically in the text. 18 datasets, 2402 tooth sites.
17 studies
GRADE not reported
Adverse events · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD -0.05 [-0.22, 0.12]
1 study · 22 participants
GRADE not reported
Included studies have not reported this outcome
Studies not reported
No studies found
MD -0.07 [-0.29, 0.15]
1 study · 22 participants
GRADE not reported
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether metronidazole + SRP changes percentage of bleeding on probing (BOP) compared with SRP (very low certainty).
3 findings from 1 review
MD -6.90 [-22.10, 8.30]
1 study · 22 participants
Very low
MD -9.00 [-16.59, -1.40]
4 studies · 108 participants
GRADE not reported
MD -4.62 [-18.83, 9.58]
2 studies · 45 participants
GRADE not reported
Cost (healthcare-system perspective): total cost per patient (GBP) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)
Clinical examination with risk-based recall showed no clear difference in cost (healthcare-system perspective): total cost per patient (GBP) compared with clinical examination with 24-month recall; GRADE not reported.
1 finding from 1 review
Wound dehiscence · Adults with mandibular third molars requiring removal
Triangular flap led to lower adverse effects (wound dehiscence) compared with envelope flap; GRADE not reported.
1 finding from 1 review