What do systematic reviews say?

Tranexamic acid vs placebo

It is very uncertain whether summary of findings: Tranexamic acid changes risk of reoperation or repeat procedure for bleeding within 7 days compared with placebo (very low certainty).

• Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and… 2023 · Cochrane Headline outcomes only
  RR 0.33 [0.01, 7.99]
  1 study · 100 participants
  Very low

Tranexamic acid vs placebo

Summary of findings: Tranexamic acid showed no clear difference in risk of a thrombotic/thromboembolic event (MI, CVA, DVT, PE) compared with placebo (low certainty).

• Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and… 2023 · Cochrane Headline outcomes only
  RR 1.1 [0.88, 1.36]
  1 study · 1360 participants
  Low

Summary of findings: Fibrin sealant vs usual care

It is very uncertain whether summary of findings: Fibrin sealant changes all‐cause mortality up to 30 days compared with usual care (very low certainty).

• Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and… 2023 · Cochrane Headline outcomes only
  RR 0.44 [0.11, 1.76]
  3 studies · 585 participants
  Very low

Summary of findings: Fibrin sealant vs usual care

The review found no eligible studies for this question.

• Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Fibrin sealant vs usual care

It is very uncertain whether summary of findings: Fibrin sealant changes risk of reoperation or repeat procedure for bleeding within 7 days compared with usual care (very low certainty).

• Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and… 2023 · Cochrane Headline outcomes only
  RR 1.03 [0.31, 3.4]
  1 study · 160 participants
  Very low

Pelvic floor muscle training (PFMT) plus biofeedback vs no treatment, sham treatment or verbal/written instruction

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 102 participants
  Low

Electrical or magnetic stimulation vs no treatment, sham treatment or verbal/written instruction

The review found no eligible studies for this question.

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Electrical or magnetic stimulation vs no treatment, sham treatment or verbal/written instruction

The review found no eligible studies for this question.

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Electrical or magnetic stimulation vs no treatment, sham treatment or verbal/written instruction

The review found no eligible studies for this question.

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Electrical or magnetic stimulation vs no treatment, sham treatment or verbal/written instruction

The review found no eligible studies for this question.

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Electrical or magnetic stimulation vs no treatment, sham treatment or verbal/written instruction

The review found no eligible studies for this question.

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Combinations of conservative treatments showed no clear difference in subjective cure or improvement: patient‐reported as defined by the… compared with no treatment, sham treatment or verbal/written instruction (low certainty).

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  RR 0.97 [0.79, 1.19]
  2 studies · 788 participants
  Low

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Combinations of conservative treatments showed no clear difference in condition‐specific quality of life: using validated questionnaires,… compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 788 participants
  Moderate

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Combinations of conservative treatments showed no clear difference in objective cure or improvement: > 6 to 12 months compared with no treatment, sham treatment or verbal/written instruction (high certainty).

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  MD 0.18
  2 studies · 565 participants
  High

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

It is very uncertain whether combinations of conservative treatments changes participant adherence to the intervention: as reported by the… compared with no treatment, sham treatment or verbal/written instruction (very low certainty).

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  RR 2.08 [0.78, 5.56]
  2 studies · 763 participants
  Very low

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Combinations of conservative treatments showed no clear difference in general quality of life: > 6 to 12 months compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 742 participants
  Moderate

Pelvic floor muscle training (PFMT) plus biofeedback vs no treatment, sham treatment or verbal/written instruction

The review found no eligible studies for this question.

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 853 participants
  Moderate

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

It is very uncertain whether combinations of conservative treatments changes number of participants experiencing muscle‐related adverse events:… compared with no treatment, sham treatment or verbal/written instruction (very low certainty).

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  RR 2.92 [0.31, 27.41]
  2 studies · 136 participants
  Very low

Pelvic floor muscle training (PFMT) plus biofeedback vs no treatment, sham treatment or verbal/written instruction

• Conservative interventions for managing urinary incontinence after prostate surgery 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 269 participants
  Low