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Evidence found and GRADE certainty

1,348 questions · 1,514 findings · 111 reviews · Oral Health

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No studies found 287 · 19%GRADE not reported 823 · 54.4%Very low 243 · 16.1%Low 104 · 6.9%Moderate 49 · 3.2%High 8 · 0.5%

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs No fluoride supplement (placebo or no treatment)

Caries increment in permanent teeth · Children and adolescents aged 16 years or less
3 findings from 1 review

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

Interproximal caries · Dentate adults aged 16 years or older (excluding orthodontic patients and those with severe periodontal disease)

The review found no eligible studies for this question.

1 finding from 1 review

Low‐level laser therapy vs Placebo or no active treatment

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Laser (low level) showed no clear difference in oral mucositis (moderate to severe) compared with placebo/sham/no treatment; GRADE not reported.

1 finding from 1 review

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

Periodontitis (clinical attachment loss) · Dentate adults aged 16 years or older (excluding orthodontic patients and those with severe periodontal disease)

The review found no eligible studies for this question.

1 finding from 1 review

Mucin spray (Saliva Orthana) vs Placebo spray (base without mucin)

Patient satisfaction / desire to continue treatment · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Mucin spray (Saliva Orthana) led to lower patient satisfaction / desire to continue treatment compared with placebo spray (base without mucin); GRADE not reported.

1 finding from 1 review
  • Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
    Sweeney 1997: majority in both groups wished to continue the allocated spray, no significant difference (Analysis 1.3). Duxbury 1989: 14/30 (46.6%) and 15/30 (50%) wished to continue Saliva Orthana and the spray base…
    2 studies
    GRADE not reported

Pilocarpine lozenge (3 mg or 5 mg) vs placebo control

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
    Single dose (up to 3 hours)
    Taweechaisupapong 2006 (crossover): participants reported a statistically significant improvement in oral dryness after both 3 mg and 5 mg pilocarpine lozenges vs placebo (P <= 0.05); no usable data presented. No…
    1 study · 33 participants
    GRADE not reported

Mucin spray (Saliva Orthana) vs Placebo spray (base without mucin)

Oral health assessment · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
    Blixt-Johansen 1992 (parallel, elderly long-term care, poor oral mucosa): oral mucosa improved in both groups but a much greater reduction in oral pathology in the mucin spray group; no data presented.
    1 study
    GRADE not reported