Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,388 questions · 1,444 findings · 167 reviews

No studies found 336 · 23.3%GRADE not reported 67 · 4.6%Very low 419 · 29%Low 395 · 27.4%Moderate 188 · 13%High 39 · 2.7%

Prostaglandin vs combined regimen

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

Prostaglandin alone showed no clear difference in women's dissatisfaction with the procedure compared with combined regimen (low certainty).

1 finding from 1 review

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Failure to achieve complete abortion · women undergoing first trimester abortion

Misoprostol 800 µg plus mifepristone 200 mg probably leads to lower failure to achieve complete abortion compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

1 finding from 1 review

Misoprostol 800 µg plus mifepristone 200 mg vs mifepristone (200 mg) plus prostaglandin

Women's dissatisfaction with the procedure · women undergoing first trimester abortion

Misoprostol 800 µg plus mifepristone 200 mg probably leads to lower women's dissatisfaction with the procedure compared with misoprostol 400 µg plus mifepristone 200 mg (moderate certainty).

1 finding from 1 review

Certolizumab pegol vs placebo

Failure to maintain clinical remission at end of study · people with Crohn's disease who responded to CZP remission‐induction treatment

Certolizumab pegol probably leads to lower failure to maintain clinical remission at week 26(1 RCT, 428… compared with placebo (moderate certainty).

1 finding from 1 review

Certolizumab pegol vs placebo

Any severe adverse event during maintenance treatment · people with Crohn's disease who responded to CZP remission‐induction treatment

Certolizumab pegol showed no clear difference in serious adverse events during remission maintenance treatment(1 RCT,… compared with placebo (low certainty).

1 finding from 1 review